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首页> 美国卫生研究院文献>Springer Open Choice >Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study
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Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study

机译：用于脂质核心检测的光学相干断层扫描衰减成像：一项体外验证研究

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Lipid-core atherosclerotic plaques are associated with disease progression, procedural complications, and cardiac events. Coronary plaque lipid can be quantified in optical coherence tomography (OCT) pullbacks by measurement of lipid arcs and lipid lengths; parameters frequently used in clinical research, but labor intensive and subjective to analyse. In this study, we investigated the ability of quantitative attenuation, derived from intravascular OCT, to detect plaque lipid. Lipid cores are associated with a high attenuation coefficient. We compared the index of plaque attenuation (IPA), a local quantitative measure of attenuation, to the manually measured lipid score (arc and length) on OCT images, and to the plaque characterization ex-vivo. We confirmed a correlation between the IPA and lipid scores (r2 > 0.7). Comparison to histology shows that high attenuation is associated with fibroatheroma, but also with macrophage presence. IPA is a robust, reproducible, and user-independent measure that facilitates quantification of coronary lipid, a potential tool in clinical research and in guiding percutaneous coronary intervention.
机译：脂质核心的动脉粥样硬化斑块与疾病的进展，程序并发症和心脏事件有关。冠状动脉斑块脂质可通过测量脂质弧和脂质长度在光学相干断层扫描（OCT）回撤中进行定量。临床研究中经常使用的参数，但劳动强度大且需要进行分析。在这项研究中，我们调查了源自血管内OCT的定量衰减检测斑块脂质的能力。脂质核与高衰减系数相关。我们将斑块衰减指数（IPA）（一种局部衰减测量）与OCT图像上手动测量的脂质评分（弧度和长度）以及离体斑块特征进行了比较。我们确认了IPA和血脂评分之间的相关性（r 2

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