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Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN)

机译:低剂量纳曲酮(LDN)治疗复杂的区域性疼痛综合征(CRPS)

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摘要

Complex Regional Pain Syndrome (CRPS) is a neuropathic pain syndrome, which involves glial activation and central sensitization in the central nervous system. Here, we describe positive outcomes of two CRPS patients, after they were treated with low-dose naltrexone (a glial attenuator), in combination with other CRPS therapies. Prominent CRPS symptoms remitted in these two patients, including dystonic spasms and fixed dystonia (respectively), following treatment with low-dose naltrexone (LDN). LDN, which is known to antagonize the Toll-like Receptor 4 pathway and attenuate activated microglia, was utilized in these patients after conventional CRPS pharmacotherapy failed to suppress their recalcitrant CRPS symptoms.
机译:复杂区域疼痛综合症(CRPS)是一种神经性疼痛综合症,涉及神经胶质激活和中枢神经系统中枢敏化。在此,我们描述了两名低剂量纳曲酮(一种神经胶质衰减剂)与其他CRPS疗法联合治疗后,两名CRPS患者的阳性结果。小剂量纳曲酮(LDN)治疗后,这两例患者缓解了明显的CRPS症状,包括肌张力障碍和固定性肌张力障碍。在传统的CRPS药物治疗未能抑制顽固的CRPS症状后,LDN在这些患者中被使用,它可以拮抗Toll样受体4通路并减弱激活的小胶质细胞。

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