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首页> 美国卫生研究院文献>Springer Open Choice >Linear Solvation Energy Relationships in the Determination of Specificity and Selectivity of Stationary Phases
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Linear Solvation Energy Relationships in the Determination of Specificity and Selectivity of Stationary Phases

机译：确定固定相的特异性和选择性时的线性溶剂能关系

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摘要

The retention of fifty structurally different compounds has been studied using linear solvation energy relationships. Investigations were performed with the use of six various stationary phases with two mobile phases (50/50 % v/v methanol/water and 50/50 % v/v acetonitrile/water). Packing materials were home-made and functionalized with octadecyl, alkylamide, cholesterol, alkyl-phosphate and phenyl molecules. This is the first attempt to compare all of these stationary phases synthesized on the same silica gel batch. Therefore, all of them may be compared in more complex and believable way, than it was performed earlier in former investigations. The phase properties (based on Abraham model) were used to the classification of stationary phases according to their interaction properties. The hydrophilic system properties s, a, b indicate stronger interactions between solute and mobile phase for most of the columns. Both e and v cause greater retention as a consequence of preferable interactions with stationary phase by electron pairs and cavity formation as well as hydrophobic bonds. However, alkyl-phosphate phase has different retention properties, as it was expressed by positive sign of s coefficient. It may be concluded that most important parameters influencing the retention of compounds are volume and hydrogen bond acceptor basicity. The LSER coefficients showed also the dependency on the type of organic modifier used as a mobile phase component.
机译：使用线性溶剂化能量关系研究了五十种结构不同的化合物的保留。使用六个固定相和两个流动相（50/50％v / v甲醇/水和50/50％v / v乙腈/水）进行研究。包装材料是自制的，并用十八烷基，烷基酰胺，胆固醇，磷酸烷基酯和苯基分子进行功能化。这是首次比较所有在同一批硅胶上合成的固定相的尝试。因此，与以前的研究相比，可以用更加复杂和可信的方式对它们进行比较。相特性（基于亚伯拉罕模型）用于根据固定相的相互作用特性对固定相进行分类。亲水系统性质s，a，b表示大多数色谱柱的溶质和流动相之间的相互作用更强。 e和v均会产生较大的保留，这是由于电子对与空穴形成以及空穴形成以及疏水键与固定相发生优选相互作用的结果。但是，磷酸烷基酯相具有不同的保留特性，因为它由s系数的正号表示。可以得出结论，影响化合物保留的最重要参数是体积和氢键受体的碱性。 LSER系数还显示出对用作流动相组分的有机改性剂类型的依赖性。

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