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首页> 美国卫生研究院文献>Springer Open Choice >In vivo biocompatibility assessment of (PTFE–PVDF–PP) terpolymer-based membrane with potential application for glaucoma treatment
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In vivo biocompatibility assessment of (PTFE–PVDF–PP) terpolymer-based membrane with potential application for glaucoma treatment

机译：（PTFE–PVDF–PP）三元共聚物膜的体内生物相容性评估及其在青光眼治疗中的潜在应用

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摘要

The aim of the work was to evaluate the in vivo biological behaviour of polymeric membrane materials for glaucoma implants. The base material was biostable synthetic terpolymer (PTFE–PVDF–PP) with proved biocompability (PN-EN ISO 10993). The samples manufactured in the form a membrane were subjected to chemical and physical treatment to create an open pore system within the polymer matrix. As a porogenic phase biodegradable natrium alginate in a fibrous form was employed. The non-perforating deep sclerectomy technique was performed in a rabbit model. The clinical observations were made after 14 and 30 days. During the study clinical symptoms of a moderate degree were observed, and histopathological changes were typical for foreign body implantation. At the end stage of the study no significant difference in histopathological assessment was found between control and experimental group. Similarities observed in both groups and relatively mild histopathological changes in the tissue surrounding the implant indicate that the observed symptoms come from a deep scleral trauma caused by surgery, and not by the presence of the implant itself.
机译：该工作的目的是评估用于青光眼植入物的聚合物膜材料的体内生物学行为。基础材料是具有生物相容性（PN-EN ISO 10993）的生物稳定的合成三元共聚物（PTFE-PVDF-PP）。将以膜形式制造的样品进行化学和物理处理，以在聚合物基质内创建一个开孔系统。作为致孔相，采用了纤维形式的可生物降解的海藻酸钠。在兔模型中进行了非穿孔深层巩膜切除术。在14和30天后进行临床观察。在研究过程中，观察到了中等程度的临床症状，并且组织病理学改变是异物植入的典型特征。在研究的最后阶段，对照组和实验组之间在组织病理学评估上没有发现显着差异。两组观察到的相似性以及植入物周围组织的相对轻微的组织病理学变化表明，观察到的症状来自手术引起的深层巩膜外伤，而不是植入物本身的存在。

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