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A Novel Stable Isotope Approach for Determining the Impact of Thickening Agents on Water Absorption

机译:确定增稠剂对吸水率影响的新型稳定同位素方法

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摘要

Research on the bioavailability of water from thickened fluids has recently been published and it concluded that the addition of certain thickening agents (namely, modified maize starch, guar gum, and xanthan gum) does not significantly alter the absorption of water from the healthy, mature human gut. Using xanthan gum as an example, our “proof of concept” study describes a simple, accurate, and noninvasive alternative to the methodology used in that first study, and involves the measurement and comparison of the dilution space ratios of the isotopes 2H and 18O and subsequent calculation of total body water. Our method involves the ingestion of a thickening agent labeled with 2H 1 day after ingestion of 18O. Analyses are based on the isotopic enrichment of urine samples collected prior to the administration of each isotope, and daily urine samples collected for 15 days postdosing. We urge that further research is needed to evaluate the impact of various thickening agents on the bioavailability of water from the developing gut and in cases of gut pathology and recommend our methodology.
机译:关于增稠液中水的生物利用度的研究最近已经发表,并且得出结论,添加某些增稠剂(即改性玉米淀粉,瓜尔豆胶和黄原胶)不会显着改变健康,成熟的水的吸收人类的内脏。以黄原胶为例,我们的“概念验证”研究描述了该第一次研究中所用方法的一种简单,准确且无创的替代方法,其中涉及同位素2的稀释空间比的测量和比较。 H和 18 O以及随后的体内总水量计算。我们的方法涉及摄入 18 O后1天摄入标记为 2 H的增稠剂。分析是基于在施用每种同位素之前收集的尿液样品的同位素富集,以及在给药后15天每天收集的尿液样品。我们敦促需要进行进一步的研究,以评估各种增稠剂对发育中的肠道以及肠道病理情况下水的生物利用度的影响,并推荐我们的方法。

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