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首页> 美国卫生研究院文献>Taylor Francis Open Select >The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaffected by exposure to 50 Hz magnetic fields
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The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaffected by exposure to 50 Hz magnetic fields

机译：胚胎小鼠大脑中X射线诱导的DNA双链断裂修复的速率不受暴露于50 Hz磁场的影响

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Purpose: Following in utero exposure to low dose radiation (10–200 mGy), we recently observed a linear induction of DNA double-strand breaks (DSB) and activation of apoptosis in the embryonic neuronal stem/progenitor cell compartment. No significant induction of DSB or apoptosis was observed following exposure to magnetic fields (MF). In the present study, we exploited this in vivo system to examine whether exposure to MF before and after exposure to 100 mGy X-rays impacts upon DSB repair rates. Materials and methods: 53BP1 foci were quantified following combined exposure to radiation and MF in the embryonic neuronal stem/progenitor cell compartment. Embryos were exposed in utero to 50 Hz MF at 300 μT for 3 h before and up to 9 h after exposure to 100 mGy X-rays. Controls included embryos exposed to MF or X-rays alone plus sham exposures. Results: Exposure to MF before and after 100 mGy X-rays did not impact upon the rate of DSB repair in the embryonic neuronal stem cell compartment compared to repair rates following radiation exposure alone. Conclusions: We conclude that in this sensitive system MF do not exert any significant level of DNA damage and do not impede the repair of X-ray induced damage.
机译：目的：在子宫内暴露于低剂量辐射（10–200 mGy）后，我们最近观察到DNA双链断裂（DSB）的线性诱导和胚胎神经元干/祖细胞区室的凋亡激活。暴露于磁场（MF）后未观察到明显的DSB诱导或凋亡。在本研究中，我们利用该体内系统检查在暴露于100 mGy X射线之前和之后暴露于MF是否对DSB修复率产生影响。材料和方法：在胚胎神经元干/祖细胞区室中，联合照射和MF后，对53BP1病灶进行定量。胚胎在暴露于100 mGy X射线之前和之后的9 h内，在子宫内以300μT的频率在50 Hz MF下暴露3 h。对照包括单独暴露于MF或X射线的胚胎以及假暴露。结果：与单独照射后的修复率相比，在100 mGy X射线之前和之后暴露于MF不会影响胚胎神经元干细胞区室中DSB的修复率。结论：我们得出的结论是，在这种敏感系统中，MF不会对DNA造成任何明显的损害，也不会阻碍X射线诱导的损害的修复。

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