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首页> 美国卫生研究院文献>Taylor Francis Open Select >Chronic Carcinogenicity Study of Gasoline Vapor Condensate (GVC) and GVC Containing Methyl Tertiary-Butyl Ether in F344 Rats
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Chronic Carcinogenicity Study of Gasoline Vapor Condensate (GVC) and GVC Containing Methyl Tertiary-Butyl Ether in F344 Rats

机译：汽油蒸气冷凝物（GVC）和含甲基叔丁基醚的GVC对F344大鼠的慢性致癌性研究

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Chronic inhalation studies were conducted to compare the toxicity and potential carcinogenicity of evaporative emissions from unleaded gasoline (GVC) and gasoline containing the oxygenate methyl tertiary-butyl ether (MTBE; GMVC). The test materials were manufactured to mimic vapors people would be exposed to during refueling at gas stations. Fifty F344 rats per gender per exposure level per test article were exposed 6 h/d, 5 d/wk for 104 wk in whole body chambers. Target total vapor concentrations were 0, 2, 10, or 20 g/m3 for the control, low-, mid-, and high-level exposures, respectively. Endpoints included survival, body weights, clinical observations, organs weights, and histopathology. GVC and GMVC exerted no marked effects on survival or clinical observations and few effects on organ weights. Terminal body weights were reduced in all mid- and high-level GVC groups and high-level GMVC groups. The major proliferative lesions attributable to gasoline exposure with or without MTBE were renal tubule adenomas and carcinomas in male rats. GMV exposure led to elevated testicular mesothelioma incidence and an increased trend for thyroid carcinomas in males. GVMC inhalation caused an increased trend for testicular tumors with exposure concentration. Mid- and high-level exposures of GVC and GMVC led to elevated incidences of nasal respiratory epithelial degeneration. Overall, in these chronic studies conducted under identical conditions, the health effects in F344 rats following 2 yr of GVC or GMVC exposure were comparable in the production of renal adenomas and carcinomas in male rats and similar in other endpoints.
机译：进行了长期吸入研究，以比较无铅汽油（GVC）和含氧化甲基叔丁基醚（MTBE; GMVC）的汽油的蒸发排放物的毒性和潜在的致癌性。测试材料的制造是为了模仿人们在加油站加油时会接触到的蒸汽。每只试验品的暴露水平按性别对50只F344大鼠进行了暴露，分别在全身室中暴露6 h / d，5 d / wk，共104 wk。对照，低，中和高水平暴露的目标总蒸气浓度分别为0、2、10或20 g / m 3 。终点包括生存率，体重，临床观察，器官重量和组织病理学。 GVC和GMVC对存活率或临床观察结果无明显影响，对器官重量的影响也很小。在所有中高级GVC组和高级GMVC组中，最终体重均降低。在有或没有MTBE的情况下，可归因于汽油暴露的主要增生性病变是雄性大鼠的肾小管腺瘤和癌。 GMV暴露导致男性睾丸间皮瘤发病率升高和甲状腺癌增加趋势。吸入GVMC会导致睾丸肿瘤的暴露浓度增加。 GVC和GMVC的中高水平暴露导致鼻呼吸道上皮变性的发生率升高。总体而言，在这些在相同条件下进行的慢性研究中，暴露2年的GVC或GMVC对F344大鼠的健康影响在雄性大鼠的肾腺瘤和癌的产生中具有可比性，在其他终点也相似。

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