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首页> 美国卫生研究院文献>Wiley-Blackwell Online Open >Design and development of low cost polyurethane biopolymer based on castor oil and glycerol for biomedical applications
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Design and development of low cost polyurethane biopolymer based on castor oil and glycerol for biomedical applications

机译：基于蓖麻油和甘油的低成本聚氨酯生物聚合物的设计和开发用于生物医学应用

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摘要

In the current study, we present the synthesis of novel low cost bio‐polyurethane compositions with variable mechanical properties based on castor oil and glycerol for biomedical applications. A detailed investigation of the physicochemical properties of the polymer was carried out by using mechanical testing, ATR‐FTIR, and X‐ray photoelectron spectroscopy (XPS). Polymers were also tested in short term in‐vitro cell culture with human mesenchymal stem cells to evaluate their biocompatibility for potential applications as biomaterial. FTIR analysis confirmed the synthesis of castor oil and glycerol based PU polymers. FTIR also showed that the addition of glycerol as co‐polyol increases crosslinking within the polymer backbone hence enhancing the bulk mechanical properties of the polymer. XPS data showed that glycerol incorporation leads to an enrichment of oxidized organic species on the surface of the polymers. Preliminary investigation into in vitro biocompatibility showed that serum protein adsorption can be controlled by varying the glycerol content with polymer backbone. An alamar blue assay looking at the metabolic activity of the cells indicated that castor oil based PU and its variants containing glycerol are non‐toxic to the cells. This study opens an avenue for using low cost bio‐polyurethane based on castor oil and glycerol for biomedical applications.
机译：在当前的研究中，我们提出了基于蓖麻油和甘油的，具有可变机械性能的新型低成本生物聚氨酯组合物的合成，用于生物医学应用。使用机械测试，ATR-FTIR和X射线光电子能谱（XPS）对聚合物的理化性质进行了详细的研究。还使用人间充质干细胞在短期体外细胞培养中测试了聚合物，以评估其生物相容性，以作为生物材料潜在应用。 FTIR分析证实了蓖麻油和甘油基PU聚合物的合成。 FTIR还显示，添加甘油作为共多元醇可增加聚合物主链内的交联度，从而增强聚合物的整体机械性能。 XPS数据表明，甘油的掺入导致聚合物表面氧化有机物质的富集。对体外生物相容性的初步研究表明，可以通过改变聚合物主链上的甘油含量来控制血清蛋白的吸附。一项针对细胞代谢活性的alamar blue分析表明，基于蓖麻油的PU及其包含甘油的变体对细胞无毒。这项研究为在生物医学应用中使用基于蓖麻油和甘油的低成本生物聚氨酯开辟了一条途径。

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