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Risk for breast cancer declined after postmenopausal hormone therapy was stopped

机译：绝经后激素治疗停止后乳腺癌风险降低

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QuestionnnIn postmenopausal women, does the increased risk for breast cancer associated with estrogen plus progestin hormone therapy continue after treatment is stopped? nnMethodsnnDesign: Randomized placebo-controlled trial (Women’s Health Initiative [WHI]).* ClinicalTrials.gov NCT00000611.nnAllocation: Concealed.†nnBlinding: Blinded during the intervention period (participants, clinicians, data collectors, outcome assessors, and safety committee).†nnFollow-up period: Mean {5.6 years}‡ during the intervention period and 2.7 years after the intervention was stopped (trial was terminated early for apparent harm).nnSetting: USA.nnPatients: 16 608 postmenopausal women 50 to 79 years of age {mean age 63 y}§ without hysterectomy or breast cancer.nnIntervention: Conjugated equine estrogens, 0.625 mg/d, plus medroxyprogesterone acetate, 2.5 mg/d {n = 8506}§, or placebo {n = 8102}§. All women were instructed to stop treatment on 8 July 2002 and {informed of their treatment group at the next follow-up visit}‡.nnOutcome: Breast cancer.nnPatient follow-up: 93% (15 387 women who did not have breast cancer at end of treatment and returned 1 follow-up questionnaire thereafter) (intention-to-treat analysis).
机译：在绝经后妇女中，停止治疗后与雌激素加孕激素激素治疗相关的乳腺癌风险增加是否继续？ nnMethodsnnDesign：随机安慰剂对照试验（妇女健康倡议[WHI]）。* ClinicalTrials.gov NCT00000611.nn分配：隐瞒。 †nn随访时间：在干预期间和停止干预后2.7年（平均试验期为{5.6年}）‡（因明显伤害而提前终止试验。）nn地点：美国。患者：16 608名50至79岁绝经后妇女{平均年龄63岁}§，无子宫切除术或乳腺癌。nn干预：共轭马雌激素0.625 mg / d，加上醋酸甲羟孕酮2.5 mg / d {n = 8506}§，或安慰剂{n = 8102}§。指示所有妇女于2002年7月8日停止治疗，{在下一次随访中告知治疗组}•nn结果：乳腺癌。nn患者随访：93％（15 387名未患乳腺癌的妇女治疗结束后返回1份后续调查表）（意向性治疗分析）。

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    《ACP Journal Club》 |2009年第6期|p.11-11|共1页
  • 作者

    Bruce E. Hillner MD;

  • 作者单位

    Virginia Commonwealth UniversityRichmond, Virginia, USA;

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