Immediate listing for liver transplantation did not differ from usual care for overall survival in stage B alcoholic cirrhosis

Jcob Korula MD

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Immediate listing for liver transplantation did not differ from usual care for overall survival in stage B alcoholic cirrhosis

机译：立即列出进行肝移植的情况与B期酒精性肝硬化的总体存活率的常规护理没有区别

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QuestionrnIn patients with Child-Pugh stage B alcoholic cirrhosis (AC),rnhow does immediate listing for liver transplantation comparernwith usual care for survival?rnMethodsrnDesign: Randomized controlled trial (RCT). ClinicalTrials.govrnNCT00701792.rnAllocation: Unclear allocation concealment.*rnBlinding: Unclear if blinded.*rnFollow-up period: 5 years.rnSetting: 13 centers from tertiary referral hospitals in France.rnPatients: 120 patients 18 to 65 years of age (mean age 50 y, 78%rnmen) who had Child-Pugh stage B AC, Béclère model R scorern< 4.04, recent recovery from Child-Pugh stage C disease, andrncomplicated cirrhosis in the past 3 months. Exclusion criteriarnincluded Child-Pugh stages A or C disease, viral hepatitis,rncancer, and contraindications to transplantation.rnIntervention: Immediate listing for liver transplantation (n = 60)rnor usual care (n = 60).rnOutcomes: Included overall survival and cancer-free survival.rnPatient follow-up: 100% (intention-to-treat analysis).

机译：问题在Child-Pugh B期酒精性肝硬化（AC）患者中，如何立即列出肝移植与通常的生存率比较？方法设计：随机对照试验（RCT）。 ClinicalTrials.govrnNCT00701792.rn分配：隐蔽的分配隐藏。* rn盲：盲目则不清楚。* rn随访时间：5年。rn地点：法国三级转诊医院的13个中心。rn患者：120名18至65岁（平均年龄）的患者50岁（78％）的人，患有Child-Pugh B期AC，Béclère模型R得分<4.04，最近从Child-Pugh C期疾病中康复，并在过去三个月内并发了肝硬化。排除标准-包括Child-Pugh A或C期疾病，病毒性肝炎，癌症和移植禁忌症。-干预：立即进行肝移植（n = 60）或常规护理（n = 60）。rn结果：包括总体生存率和癌症-患者免费随访：100％（意向性治疗分析）。

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《ACP Journal Club》 |2009年第1期|p.14-14|共1页
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Jcob Korula MD;
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Arcadia, California, USA;

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1. Immediate Listing for Liver Transplantation Versus Standard Care for Child–Pugh Stage B Alcoholic Cirrhosis: A Randomized Trial [J] . Claire Vanlemmens Vincent Di Martino Chantal Milan Michel Messner Anne Minello Christophe Duvoux Thierry Poynard Jean-Marc Perarnau Marie-Anne Astrid Piquet Georges-Philippe Pageaux Sébastien Dharancy Christine Silvain Sophie Hillaire Gérard Thiefin Jean-Pierre Vinel Patrick Hillon Estelle Collin Georges Mantion Jean-Philippe Miguet and the TRANSCIAL Study Group Annals of Internal Medicine . 2009,第3期

机译：肝移植立即上市与Child-Pugh B期酒精性肝硬化的标准治疗：一项随机试验
2. Immediate listing for liver transplantation versus standard care for Child-Pugh stage B alcoholic cirrhosis: a randomized trial. [J] . Vanlemmens C, Di-Martino V, Milan C, Annals of Internal Medicine . 2009,第3期

机译：立即进行肝移植与标准治疗有关Child-Pugh B期酒精性肝硬化的清单：一项随机试验。
3. De novo Malignancy and Recurrent Alcoholic Cirrhosis Account for 70% of Deaths in Patients Transplanted for End-Stage Alcoholic Liver Disease [J] . Verbeek Jef, Cassiman David, Nevens Frederik The American Journal of Gastroenterology . 2016,第3期

机译：从头开始的恶性肿瘤和复发性酒精性肝硬化占晚期酒精性肝病移植患者死亡的70％
4. Effect of Intrahepatic Arterial and Intraportal Administration of FK506 on Liver Transplantation Survival for Unresectable Progressive Liver Cancer and Possible Prevention of Tumor Recurrence in Rats [C] . K. Yano, R. Sumimoto, Y. Fukuda, European Society for Surgical Research . 2006

机译：FK506肝内动脉和内部施用对肝移植肝癌肝移植存活的影响及可能预防大鼠肿瘤复发
5. Predicting outcomes post liver transplantation in patients with primary biliary cirrhosis and primary sclerosing cholangitis. [D] . Zapatochny Rufo, Rebecca Jo. 2003

机译：预测原发性胆汁性肝硬化和原发性硬化性胆管炎患者肝移植后的结局。
6. Causes of Death and Survival in Alcoholic Cirrhosis Patients Undergoing Liver Transplantation: Influence of the Patient’s Clinical Variables and Transplant Outcome Complications [O] . J. M. Bolarín, M. D. Pérez-Cárceles, J. P. Hernández del Rincón, 2021

机译：患有肝脏移植的酒精性肝硬化患者死亡和生存的原因：患者临床变量和移植结果并发症的影响
7. Features of the State of Internal Organs and the Structure of Comorbidity in Deceased Persons With Alcoholic Liver Cirrhosis, Non-alcoholic Fatty Liver Disease at the Cirrhosis Stage and Alcoholic Liver Cirrhosis Associated With Insulin Resistance and Obesity [O] . N. Matkovska 2020

机译：内脏状态的特征以及死者肝硬化的死者肝硬化中的合并症结构，肝硬化阶段的非酒精脂肪肝病和血液肝硬化与胰岛素抵抗和肥胖相关

Immediate listing for liver transplantation did not differ from usual care for overall survival in stage B alcoholic cirrhosis

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