Systematic Review: Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes

Rehan Qayyum Shari Bolen Nisa Maruthur Leonard Feldman Lisa M. Wilson Spyridon S. Marinopoulos Padmini Ranasinghe Muhammed Amer and Eric B. Bass

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Systematic Review: Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes

机译：系统评价：2型糖尿病中预混胰岛素类似物的比较有效性和安全性

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Premixed insulin analogues are a mixture of short-acting and intermediate-acting insulin analogues. Their effectiveness relative to other antidiabetic agents is not clearly established. This systematic review of comparative trials in adults with type 2 diabetes found that premixed insulin analogues and premixed human insulin provided similar glycemic control. Premixed insulin analogues provided tighter glycemic control and caused more hypoglycemia than did long-acting insulin analogues and noninsulin antidiabetic agents. Evidence for effects on clinical outcomes of diabetes, however, was scant and inconclusive.

机译：预混合的胰岛素类似物是短效和中效胰岛素类似物的混合物。相对于其他抗糖尿病药的有效性尚不清楚。这项对2型糖尿病成人进行的比较试验的系统综述发现，预混胰岛素类似物和预混人胰岛素可提供相似的血糖控制。与长效胰岛素类似物和非胰岛素抗糖尿病药相比，预混胰岛素类似物可提供更严格的血糖控制，并引起更多的低血糖症。然而，对糖尿病临床预后影响的证据很少且没有定论。

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来源
《ACP Journal Club》 |2008年第8期|p.549-559|共11页
作者
Rehan Qayyum Shari Bolen Nisa Maruthur Leonard Feldman Lisa M. Wilson Spyridon S. Marinopoulos Padmini Ranasinghe Muhammed Amer and Eric B. Bass;
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From Evidence-based Practice Center, Johns Hopkins University, Baltimore, Maryland.;

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原文格式 PDF
正文语种 eng
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关键词
Type 2 Diabetes; Premixed Insulin Analogues;

机译：2型糖尿病;预混胰岛素类似物;

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1. Systematic Review: Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes [J] . Rehan Qayyum MD, Shari Bolen MD MPH, Nisa Maruthur MD MHS, Annals of Internal Medicine . 2008,第8期

机译：系统评价：2型糖尿病中预混胰岛素类似物的比较有效性和安全性
2. Systematic review: comparative effectiveness and safety of premixed insulin analogues in type 2 diabetes. [J] . Qayyum R, Bolen S, Maruthur N, Annals of Internal Medicine . 2008,第8期

机译：系统评价：2型糖尿病中预混胰岛素类似物的比较有效性和安全性。
3. AHRQ's Comparative Effectiveness Research on Premixed Insulin Analogues for Adults with Type 2 Diabetes: Understanding and Applying the Systematic Review Findings [J] . Laurence Greene, Rehan Qayyum Journal of Managed Care & Specialty Pharmacy . 2015,第3aSuppaA期

机译：AHRQ对成人2型糖尿病预混胰岛素类似物的比较功效研究：了解和应用系统评价结果
4. Switching to insulin glargine 300 U/mL from other basal insulin analogues provides less 24-hour glucose variability in hospitalized patients with type 1 diabetes [C] . V.V. Klimontov, E.A. Koroleva, O.N. Fazullina International Multiconference Bioinformatics of Genome Regulation and StructureSystems Biology . 2018

机译：从其他基础胰岛素类似物转换为甘精胰岛素300 U / mL可使住院的1型糖尿病患者的24小时葡萄糖变异性降低
5. Risk of Any Hypoglycemia with New Antihyperglycemic Agents in Patients with Type 2 Diabetes: A Systematic Review and Meta-analysis [D] . Kamalinia, Sanaz. 2019

机译：患有2型糖尿病患者的新抗血糖药物的任何低血糖症的风险：系统审查和荟萃分析
6. Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes [O] . Rehan Qayyum, Shari Bolen, Nisa Maruthur, -1

机译：2型糖尿病中预混胰岛素类似物的比较有效性和安全性
7. Systematic review and meta-analysis of randomized clinical trials comparing efficacy and safety outcomes of insulin glargine with NPH insulin, premixed insulin preparations or with insulin detemir in type 2 diabetes mellitus [O] . 2015

机译：系统评价和荟萃分析比较甘精胰岛素与NPH胰岛素，预混胰岛素制剂或与Detemir胰岛素治疗2型糖尿病的疗效和安全性
8. Comparative Effectiveness, Safety, and Indications of Insulin Analogues in Premixed Formulations for Adults With Type 2 Diabetes. Executive Summary. Effective Health Care Report Number 14 [R] . 2008

机译：2型糖尿病患者预混配方中胰岛素类似物的比较效果，安全性和适应症。执行摘要。有效的医疗保健报告第14号

Systematic Review: Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes

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