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首页> 外文期刊>Acta Neuropathologica >Spontaneous human herpes virus type 1 infection in a chinchilla (Chinchilla lanigera f. dom.)
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Spontaneous human herpes virus type 1 infection in a chinchilla (Chinchilla lanigera f. dom.)

机译：黄鼠（Chinchilla lanigera f。dom。）中的自发性人类疱疹病毒1型感染。

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摘要

A 1-year-old male chinchilla with a 2-week history of conjunctivitis suffered subsequently from neurological signs comprising seizures, disorientation, recumbency and apathy. After 3 weeks of progressive central nervous disease the animal was killed in view of the poor prognosis. A non-suppurative meningitis and polioencephalitis with neuronal necrosis and intranuclear inclusion bodies were observed at necropsy and by light microscopy. The brain stem and cerebral cortices were most severely affected. Both eyes displayed ulcerative keratitis, uveitis, retinitis and retinal degeneration, and optical neuritis. Additionally, a purulent rhinitis with focal erosions, epithelial degeneration and intranuclear inclusion bodies was present. Ultrastructurally, herpes virus particles were detected in neurons of the brain. Immunohistochemistry with antisera specific for human herpes virus types 1 and 2 resulted in viral antigen labeling in neurons, glial cells and in neuronal processes. Viral antigen was found in the rhinencephalon, cerebral cortices, hippocampus, numerous nuclei of the brain stem, single foci in the cerebellum, and in a solitary erosive lesion of the right nasal vestibulum. Viral antigen was not detected in the eyes. The virus was isolated from the CNS, and nucleic acid sequence analysis of the glycoprotein B and the DNA polymerase revealed a sequence homology with human herpes virus type 1 of 99% and 100%, respectively. The clinical signs, the distribution of the lesions and the viral antigen suggest a primary ocular infection with subsequent spread to the CNS. Chinchillas are susceptible to human herpes virus 1 and may play a role as a temporary reservoir for human infections.
机译：患有结膜炎2周史的1岁雄性黄鼠其后出现神经系统症状，包括癫痫发作，迷失方向，卧倒和冷漠。考虑到不良的预后，在进行性中枢神经疾病进行三周后将动物处死。尸检和光学显微镜观察发现非化脓性脑膜炎和脊髓灰质炎并伴有神经元坏死和核内包涵体。脑干和大脑皮层受到的影响最大。两只眼睛均显示溃疡性角膜炎，葡萄膜炎，视网膜炎和视网膜变性以及视神经炎。此外，还存在化脓性鼻炎，伴有局部糜烂，上皮变性和核内包涵体。在超微结构中，在大脑神经元中检测到疱疹病毒颗粒。用针对1型和2型人类疱疹病毒的抗血清的免疫组织化学方法在神经元，神经胶质细胞和神经元过程中产生了病毒抗原标记。在鼻脑，大脑皮层，海马，脑干的众多核，小脑的单个病灶以及右鼻前庭的单个糜烂性病变中发现了病毒抗原。在眼睛中未检测到病毒抗原。该病毒是从CNS中分离出来的，糖蛋白B和DNA聚合酶的核酸序列分析显示与1型人类疱疹病毒的序列同源性分别为99％和100％。临床体征，病变分布和病毒抗原提示原发性眼部感染，随后扩散至中枢神经系统。龙猫容易感染人类疱疹病毒1，并可能充当人类感染的临时宿主。

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  • 来源
    《Acta Neuropathologica》 |2002年第6期|674-678|共5页
  • 作者

    P. Wohlsein; A. Thiele; M. Fehr; L. Haas; K. Henneicke; D. Petzold; W. Baumgärtner;

  • 作者单位

    Department of Pathology School of Veterinary Medicine Hannover Bünteweg 17 30559 Hannover Germany;

    Clinic for Small Domestic Animals School of Veterinary Medicine Hannover Bischofsholer Damm 15 30171 Hannover Germany;

    Clinic for Small Domestic Animals School of Veterinary Medicine Hannover Bischofsholer Damm 15 30171 Hannover Germany;

    Department of Virology School of Veterinary Medicine Hannover Bünteweg 17 30559 Hannover Germany;

    Laboratory for Pathology Hannover Berliner Allee 45 30175 Hannover Germany;

    Department of Virology Hannover School of Medicine Konstanty-Gutschow Str. 1 30173 Hannover Germany;

    Department of Pathology School of Veterinary Medicine Hannover Bünteweg 17 30559 Hannover Germany;

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  • 关键词

    Human herpes virus type 1 Encephalitis Immunohistochemistry Polymerase chain reaction Chinchilla;

    机译：1型人疱疹病毒脑炎免疫组织化学聚合酶链反应;

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