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首页> 外文期刊>Acta Pharmacologica Sinica >Association of vitamin D receptor and estrogen receptor-α gene polymorphism with peak bone mass and bone size in Chinese women
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Association of vitamin D receptor and estrogen receptor-α gene polymorphism with peak bone mass and bone size in Chinese women

机译：维生素D受体和雌激素受体α基因多态性与中国女性峰值骨量和骨大小的关系

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摘要

AIM: To investigate if vitamin D receptor (VDR) gene Apa Ⅰ polymorphism and estrogen receptor-α (ER-α) gene Pvu Ⅱ, Xba Ⅰ polymorphisms are related to bone mineral density (BMD), bone mineral content (BMC) and bone size in premenopausal Chinese women. METHODS: The VDR Apa Ⅰ genotype and ER-α Pvu II, Xba Ⅰ genotype were determined by PCR-restriction fragment length polymorphism (RFLP) in 493 unrelated healthy women aged 20-40 years of Han nationality in Shanghai city. BMD (g/cm~2), BMC (g), and bone areal size (BAS, cm~2) at lumbar spine 1-4 (L_(14)) and proximal femur (femoral neck, trochanter and Ward's triangle) were measured by duel-energy X-ray absorptionmetry. RESULTS: All allele frequencies did not deviate from Hardy-Weinberg equilibrium. After pheno-types were adjusted for age, height, and weight, a significant association was found between VDR Apa Ⅰ genotype and BMC variation at L_(14) and Ward's triangle (P<0.05), but not in BMD or BAS at lumbar spine and proximal femur. ER-α Pvu Ⅱ, Xba Ⅰ genotype was not related to BMC, BMD, and BAS at all sites. CONCLUSION: The study suggested that Apa Ⅰ polymorphism in VDR gene may influence on attainment and maintenance of peak bone mass in premenopausal Chinese women.
机译：目的：探讨维生素D受体（VDR）基因ApaⅠ多态性和雌激素受体-α（ER-α）基因PvuⅡ，XbaⅠ多态性是否与骨矿物质密度（BMD），骨矿物质含量（BMC）和骨骼有关绝经前中国妇女的体型。方法：采用PCR-限制性片段长度多态性（RFLP）技术，对上海地区493例20〜40岁汉族健康女性进行VDR ApaⅠ基因型和ER-αPvu II，XbaⅠ基因型的测定。腰椎1-4（L_（14））和股骨近端（股骨颈，转子和沃德三角）的BMD（g / cm〜2），BMC（g）和骨面积大小（BAS，cm〜2）为用决斗能量X射线吸收法测定。结果：所有等位基因频率均未偏离Hardy-Weinberg平衡。调整表型以适应年龄，身高和体重后，L_（14）和沃德三角形处的VDR ApaⅠ基因型与BMC变异之间存在显着相关性（P <0.05），而腰椎的BMD或BAS则无此关联和股骨近端。 ER-αPvuⅡ，XbaⅠ基因型在所有位点均与BMC，BMD和BAS无关。结论：研究表明，VDR基因的ApaⅠ多态性可能影响绝经前中国女性峰值骨量的获得和维持。

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