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首页> 外文期刊>Acta Pharmacologica Sinica >Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage
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Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage

机译：PDCD5，一种新型的凋亡相关蛋白，在人骨关节炎软骨中的表达

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AIM: To investigate the expression features of PDCD5 (programmed cell death 5 protein) in osteoarthritic and normal human cartilage, and speculate on its potential functions in the pathogenesis of osteoarthritis (OA). METHODS: Articular cartilage specimens were obtained from 30 patients with OA and 16 healthy patients at the time of arthroplasty. Expression of PDCD5 was detected by flow cytometry, immunofluorescence, RT-PCR and immunohistochemical analysis. RESULTS: Enhanced expression and nuclear accumulation of PDCD5 in OA chondrocytes were found. PDCD5-positive chondrocytes were mainly distributed in the superficial and deep zones of OA tissue sections, as opposed to, in the superficial and middle regions of normal healthy tissue sections. CONCLUSION: Since apoptotic chondrocyte death occurs more frequently in OA cartilage than in normal healthy cartilage and PDCD5 is an apoptosis-related protein, the different expression patterns of PDCD5 in OA cartilage from that in normal healthy cartilage indicate that PDCD5 is involved in the pathogenesis of OA.
机译：目的：研究PDCD5（程序性细胞死亡5蛋白）在骨关节炎和正常人软骨中的表达特征，并推测其在骨关节炎（OA）发病机理中的潜在功能。方法：关节置换时从30例OA患者和16例健康患者中获取关节软骨标本。通过流式细胞术，免疫荧光，RT-PCR和免疫组化分析检测PDCD5的表达。结果：发现PDCD5在OA软骨细胞中的表达增强和细胞核蓄积。 PDCD5阳性软骨细胞主要分布在OA组织切片的浅表和深部区域，而不是正常健康组织切片的浅表和中部区域。结论：由于凋亡性软骨细胞死亡在OA软骨中比在正常健康软骨中更频繁，并且PDCD5是一种凋亡相关蛋白，因此OA软骨中PDCD5与正常健康软骨中不同的表达模式表明PDCD5参与了OA软骨的发病机理。 OA。

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