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首页> 外文期刊>Acta Pharmacologica Sinica >Effects of estrogen on gastrocnemius muscle strain injury and regeneration in female rats
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Effects of estrogen on gastrocnemius muscle strain injury and regeneration in female rats

机译：雌激素对雌性大鼠腓肠肌肌张力损伤和再生的影响

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AIM: To study the effects of estrogen on muscle damage and regeneration after acute passive gastrocnemius muscle strain injury in female Sprague-Dawley rats. METHODS: Rats were divided into 5 groups: ovariectomi/ed, strained and treated with low-dosage estradiol (20 μg/d) (E_(low)), treated with high-dosage estradiol (200 μg/d) (E_(high)), treated with oil placebo (Oil), strained with no ovariectomy (Strain), and sham operated with no strain and no ovariectomy (Con). Muscle damage index [plasma creatine kinase (CK)], antioxidant indexes [glutathione (GSH), Vitamin E (Vit E), total antioxidant capability (TAC)], and muscle regeneration index (desmin) were investigated at 7 d. RESULTS: The plasma CK activity increased but GSH, Vit E, and TAC levels decreased after muscle strain injury (Strain vs Con P<0.05). Plasma CK activity was the greatest while GSH, Vit E, and TAC were the lowest in the Oil group among the five groups (P<0.01). Plasma CK in the E_(high) and Strain groups was lower than that in the E_(low) group. Plasma GSH, Vit E, and TAC were higher in the E_(high) and Strain groups compared with the E_(low) group (P <0.05). The expression of desmin in the E_(high) and Strain groups was higher than that in the E_(low) group (P<0.01) while that in the Oil group was the lowest in all the five groups (P<0.01). CONCLUSION: Endogenous estrogen in normal female rats or exogenous estrogen in ovariectomized rats could improve antioxidant capability in vivo, so that reduced muscle damage and accelerated muscle regeneration post gastronemius muscle strain injury.
机译：目的：研究雌激素对雌性Sprague-Dawley大鼠急性被动腓肠肌劳损后肌肉损伤和再生的影响。方法：将大鼠分为5组：卵巢切除/灌胃，拉伤并用低剂量雌二醇（20μg/ d）治疗（E_（低）），高剂量雌二醇（200μg/ d）（E_（高）），用油安慰剂（Oil）进行治疗，不进行卵巢切除术（Strain）进行劳损，并且进行假手术，不进行应变和卵巢切除术（Con）。在7天时研究了肌肉损伤指数[血浆肌酸激酶（CK）]，抗氧化剂指数[谷胱甘肽（GSH），维生素E（Vit E），总抗氧化能力（TAC）]和肌肉再生指数（desmin）。结果：肌肉拉伤后血浆CK活性升高，但GSH，Vit E和TAC水平降低（Strain vs Con P <0.05）。在五组油组中，血浆CK活性最高，而GSH，Vit E和TAC最低（P <0.01）。 E_（高）和应变组的血浆CK低于E_（低）组。 E_（高）和应变组的血浆GSH，Vit E和TAC高于E_（低）组（P <0.05）。 E_（高）和应变组的结蛋白表达高于E_（低）组（P <0.01），而油组最低（五组）（P <0.01）。结论：正常雌性大鼠的内源性雌激素或去卵巢大鼠的外源性雌激素可提高体内抗氧化能力，从而减少腓肠肌劳损后的肌肉损伤并加速肌肉再生。

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