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首页> 外文期刊>Acta Pharmacologica Sinica >Putative caveolin-binding sites in SARS-CoV proteins
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Putative caveolin-binding sites in SARS-CoV proteins

机译：SARS-CoV蛋白中假定的小孔蛋白结合位点

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摘要

AIM: To obtain the information of protein-protein interaction between the SARS-CoV proteins and caveolin-1, identify the possible caveolin-binding sites in SARS-CoV proteins. METHODS: On the basis of three related caveolin-binding motifs, amino acid motif search was employed to predict the possible caveolin-1 related interaction domains in the SARS-CoV proteins. The molecular modeling and docking simulation methods were used to confirm the interaction between caveolin-1 and SARS-CoV proteins. RESULTS: Thirty six caveolin-binding motifs in the SARS-CoV proteins have been mapped out using bioinformatics analysis tools. Molecular modeling and simulation have confirmed 8 caveolin-binding sites. These caveolin-binding sites located in replicase 1AB, spike protein, orf3 protein, and M protein, respectively. CONCLUSION: Caveolin-1 may serve as a possible receptor of the SARS-CoV proteins, which may be associated with the SARS-CoV infection, replication, assembly, and budding.
机译：目的：为了获得SARS-CoV蛋白和caveolin-1之间蛋白-蛋白相互作用的信息，确定SARS-CoV蛋白中可能的caveolin结合位点。方法：在三个相关的caveolin结合基序的基础上，采用氨基酸基序搜索来预测SARS-CoV蛋白中可能与caveolin-1相关的相互作用域。分子建模和对接模拟方法被用来确认caveolin-1和SARS-CoV蛋白之间的相互作用。结果：利用生物信息学分析工具，SARS-CoV蛋白中的36个小窝蛋白结合基序已经被标出。分子建模和模拟已经确认了8个小窝蛋白结合位点。这些小窝蛋白结合位点分别位于复制酶1AB，刺突蛋白，orf3蛋白和M蛋白中。结论Caveolin-1可能是SARS-CoV蛋白的一种可能受体，可能与SARS-CoV的感染，复制，组装和萌芽有关。

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