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首页> 外文期刊>Acta Pharmacologica Sinica >Effects of scutellarin on liver function after brain ischemia/reperfusion in rats
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Effects of scutellarin on liver function after brain ischemia/reperfusion in rats

机译：黄cut苷对大鼠脑缺血/再灌注后肝功能的影响

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AIM: To investigate the effects of scutellarin (Scu) on liver function after brain ischemia/reperfusion in Wistar rats. METHODS: Rats were pretreated with Scu for 7 d and then subjected to a brain ischemia/reperfusion injury induced by a middle cerebral artery occlusion. The levels of nitric oxide (NO), xanthine oxidase (XOD), alanine transaminase (ALT), and aspartate aminotransferase (AST) in serum or liver tissues and the activities of antioxidant enzymes and cytochrome P450-dependent monooxygenases (CYPs) in liver tissues after brain ischemia/reperfusion were determined. RESULTS: In vehicle-treated rats, XOD, ALT, and AST activities (P<0.01) in serum and the MDA level (P<0.05) in liver tissues were all elevated but were significantly reduced (P<0.05) by Scu pretreatment. The NO levels in serum and liver tissues were decreased (P<0.01) dramatically in vehicle-treated rats and returned to the levels in the sham-operated animals when pretreated with Scu. SOD (P<0.05) and GSH-PX (P<0.01) activities in cytosol fraction were increased significantly by Scu pretreatment. Furthermore, a loss of CYP3A activity (P<0.01), but no changes of CY1P1A1, CYP1A2, and CYP2E1 activities in liver were observed after brain ischemia/reperfusion in rats. Scu had no effect on them. CONCLUSION: These results demonstrated that pretreatment with Scu could attenuate hepatocellular damage elicited by brain ischemia/reperfusion in rats and this protection is in major part by its antioxidant activity.
机译：目的：研究黄cut苷（Scu）对Wistar大鼠脑缺血/再灌注后肝功能的影响。方法：大鼠用Scu预处理7 d，然后遭受大脑中动脉闭塞引起的脑缺血/再灌注损伤。血清或肝组织中一氧化氮（NO），黄嘌呤氧化酶（XOD），丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）的水平以及肝组织中抗氧化酶和细胞色素P450依赖性单加氧酶（CYP）的活性确定脑缺血/再灌注后。结果：经媒介处理的大鼠血清中的XOD，ALT和AST活性（P <0.01）和肝组织中的MDA水平（P <0.05）均升高，但经Scu预处理显着降低（P <0.05）。用Scu预处理后，用赋形剂处理的大鼠的血清和肝组织中的NO水平显着降低（P <0.01），并恢复到假手术动物中。 Scu预处理显着提高了细胞溶质中的SOD（P <0.05）和GSH-PX（P <0.01）活性。此外，在大鼠脑缺血/再灌注后，肝脏中CYP3A活性丧失（P <0.01），但未观察到肝中CY1P1A1，CYP1A2和CYP2E1活性的变化。 Scu对他们没有影响。结论：这些结果表明，Scu预处理可以减轻大鼠脑缺血/再灌注引起的肝细胞损伤，而这种保护作用主要是由于其抗氧化活性。

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