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首页> 外文期刊>Acta Pharmacologica Sinica >Effects of konjac extract on insulin sensitivity in high fat diet rats
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Effects of konjac extract on insulin sensitivity in high fat diet rats

机译：魔芋提取物对高脂饮食大鼠胰岛素敏感性的影响

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AIM: To evaluate the effects of konjac extract (KE) on insulin sensitivity in insulin resistance (IR) rats induced by high fat diet (HFD). METHODS: Wistar rats were fed on HFD for 4 weeks, then treated with KE 1.5, 3.0 g·kg~(-1)·d~(-1) and metformin (Met) 0.1 g·kg~(-1)·d~(-1) for 4 weeks, respectively. The effects of KE on intake of food and drink, body weight, and excretion were investigated. Serum insulin was measured by double-radioimmunoassay. Blood glucose, total cholesterol (TC), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-C) were measured by enzyme methods, respectively. Low-density lipoprotein-cholesterol (LDL-C) was calculated. Tissue glycogen was determined by modified anthracene ketone method and tissue TG by glycerin phosphor sour oxidation enzyme method. Insulin sensitivity was measured by modified glucose-insulin tolerance test (K value). RESULTS: HFD caused IR after 4 weeks (K value: 5.2 +- 0.9 vs 8.3 +- 0.7, P<0.01), the levels of blood insulin, TG, and LDL-C increased, while HDL-C, glycogen in liver and skeletal muscle decreased. The. storage of TG in liver and skeletal muscle increased. After HFD rats were treated with KE 1.5 and 3.0 g·kg~(-1)·d~(-1) for 4 weeks, respectively, the fasting blood glucose (FBG) was decreased from 6.4 +- 0.4 to 6.05 +- 0.26, 6.0 +- 0.3 (P<0.01). Serum TC, TG, LDL-C were decreased, while HDL-C/TC was increased as compared with HFD rats. There was no significant effect on insulin level. KE 1.5, 3.0 g·kg~(-1)·d~(-1), and Met 0.1 g·kg~(-1)·d~(-1) could improve insulin sensitivity (K values were 6.1 +- 0.5, 5.9 +- 0.6, and 6.5 +- 0.8 vs 5.2 +- 0.9, P<0.05), elevate glycogen, and decrease TG in liver and skeletal muscle. CONCLUSION: KE could promote glycogen syntheses and adjust blood lipid metabolism so as to improve IR in HFD rats.
机译：目的：评价魔芋提取物（KE）对高脂饮食（HFD）诱导的胰岛素抵抗（IR）大鼠胰岛素敏感性的影响。方法：Wistar大鼠HFD喂养4周，用KE 1.5、3.0 g·kg〜（-1）·d〜（-1）和二甲双胍（Met）0.1 g·kg〜（-1）·d治疗〜（-1）分别为4周。研究了KE对食物和饮料摄入，体重和排泄的影响。通过双重放射免疫测定法测定血清胰岛素。通过酶法分别测定血糖，总胆固醇（TC），甘油三酸酯（TG）和高密度脂蛋白胆固醇（HDL-C）。计算了低密度脂蛋白胆固醇（LDL-C）。用改进的蒽酮法测定组织糖原，用甘油磷酸氧化酶法测定组织TG。通过改良的葡萄糖-胰岛素耐受性测试（K值）测量胰岛素敏感性。结果：HFD在4周后引起IR（K值：5.2±0.9 vs 8.3±0.7，P <0.01），血液胰岛素，TG和LDL-C水平升高，而HDL-C，肝和肝糖原水平升高骨骼肌减少。的。 TG在肝和骨骼肌中的储存增加。分别以KE 1.5和3.0 g·kg〜（-1）·d〜（-1）处理HFD大鼠4周后，空腹血糖（FBG）从6.4 +-0.4降低至6.05 +-0.26 ，6.0±0.3（P ＜0.01）。与HFD大鼠相比，血清TC，TG，LDL-C降低，而HDL-C / TC升高。对胰岛素水平无明显影响。 KE 1.5、3.0 g·kg〜（-1）·d〜（-1）和Met 0.1 g·kg〜（-1）·d〜（-1）可以改善胰岛素敏感性（K值为6.1 +-0.5 ，分别为5.9 +-0.6和6.5 +-0.8与5.2 +-0.9，P <0.05），升高肝糖原，并降低肝脏和骨骼肌的TG。结论：KE可促进HFD大鼠糖原合成，调节血脂代谢，改善IR。

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