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首页> 外文期刊>Acta Pharmacologica Sinica >Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza)
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Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza)

机译：不同商品原料药和丹参制剂中四种活性成分的含量

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AIM: To detect the contents of four active components of Salvia miltiorrhiza in various commercially available danshen crude drugs and preparations. METHODS: Commercially available danshen crude drugs from different sources, as well as danshen pills and intravenous injection preparations containing danshen alone or in combination with other herbs were collected. The composition of these danshen samples was analyzed using HPLC. Specifically, the amounts of magnesium tanshinoate B (MTB), danshensu, isotanshinone Ⅱ_A, and cryptotanshinone were determined. In some of these samples, the content of MTB was further confirmed by liquid chromatography-tandem mass spectrometer (LC-MS)/MS method. RESULTS: There were great variations in the amount of the four active ingredients in the commercially available danshen crude drugs and drug preparations in this study. The amount of MTB was the highest among the four components measured in the crude drugs. However, the amounts of MTB in all danshen preparations were much lower than those in crude drugs. The 2 lipophilic components, isotanshinone Ⅱ_A and cryptotanshinone, were very low or not detectable in both injection and oral preparations. CONCLUSION: MTB can be used to standardize the various forms of danshen crude drugs and drug preparations from different sources. In view of the variation in the amounts of MTB and other components, improvement in the production methods of danshen preparations is essential to ensure consistent amount of its active ingredients and reproducible pharmacological actions.
机译：目的：检测丹参原料药和制剂中丹参中四种有效成分的含量。方法：收集不同来源的市售丹参原料药，以及仅含丹参或与其他草药合用的丹参丸和静脉注射制剂。使用HPLC分析这些丹参样品的组成。具体而言，测定了丹参酸镁B（MTB），丹参素，异丹参酮Ⅱ_A和隐丹参酮的含量。在其中一些样品中，MTB含量通过液相色谱-串联质谱仪（LC-MS）/ MS方法进一步确定。结果：本研究中市售的丹参原料药和药物制剂中四种活性成分的含量差异很大。在原料药中测得的四种成分中，MTB的含量最高。但是，所有丹参制剂中的MTB含量均远低于原料药中的MTB含量。注射和口服制剂中的两种亲脂性成分异丹参酮Ⅱ_A和隐丹参酮含量极低或无法检测到。结论：MTB可用于标准化各种形式的丹参原料药和不同来源的药物制剂。考虑到MTB和其他成分含量的变化，改善丹参制剂的生产方法对于确保一致的活性成分含量和可再现的药理作用至关重要。

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