Class Ⅲ anti-arrhythmia drug E-4031 potentiates Na~2+/Ca~2+ exchange current in rat ventricular myocytes

Wu Dong-Mei; Lu Ji-Yuan; Wu Bo-Wei

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Class Ⅲ anti-arrhythmia drug E-4031 potentiates Na~2+/Ca~2+ exchange current in rat ventricular myocytes

机译：Ⅲ类抗心律失常药物E-4031增强大鼠心室肌细胞Na〜2 + / Ca〜2 +交换电流

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At potential of + 50 mV, E-4031 5, 10, and 20μmol.L~-1 increased Ni~2+ -sensitive current from (0. 48±0.12), to(0.78±0.20), (0.96±0.16), and (1. (1.15±0.13)pA/pF, respectively; tetrade- canoylphorbol acetate(TPA) 50 nmol.L~-1 increased Ni~2+ -sensitive current from (0.60±0.16)to(1.33± 0.25)pA/pF. E-4031 stimulates the Na~+/ Ca~2+ exchange via a protein kinase C-dependent path- Way.

机译：在+ 50 mV的电位下，E-4031 5、10和20μmol.L〜-1使Ni〜2 +敏感电流从（0. 48±0.12）增加到（0.78±0.20），（0.96±0.16）；和（1.（1.15±0.13）pA / pF；分别为50 nmol.L〜-1的四乙酸十二烷酰佛波酯（TPA）将Ni〜2 +敏感电流从（0.60±0.16）增加到（1.33±0.25） pA / pF。E-4031通过蛋白激酶C依赖性途径刺激Na〜+ / Ca〜2 +交换。

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《Acta Pharmacologica Sinica》 |2000年第3期|p.249-252|共4页
作者
Wu Dong-Mei; Lu Ji-Yuan; Wu Bo-Wei;
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正文语种 eng
中图分类药理学;
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E-4301; anti-arrhythmia agents; tamoxifen;

机译：E-4301;抗心律失常药;他莫昔芬;

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1. E-4031 enhanced Ca~(2+) transient and ventricular myocytes contraction via reverse mode Na~+/Ca~(2+) exchange in normal and hypertrophic rats [J] . CUI Xiang-Li, ZHAO Lu-Ying, WU Bo-Wei Acta Pharmacologica Sinica . 2002,第9期

机译：在正常和肥大大鼠中，E-4031通过逆向Na〜+ / Ca〜（2+）交换增强了Ca〜（2+）瞬时和心室肌细胞的收缩
2. α_1-Adrenoceptor stimulation potentiates L-type Ca~(2+) current through Ca~(2+)/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes [J] . Jin O-Uchi, Kimiaki Komukai, Yoichiro Kusakari, Proceedings of the National Academy of Sciences of the United States of America . 2005,第26期

机译：α_1-肾上腺素能受体刺激通过大鼠心室肌细胞中Ca〜（2 +）/钙调蛋白依赖性PK II（CaMKII）激活增强L型Ca〜（2+）电流
3. Profile of L-type Ca 2+ current and Na +/Ca 2+ exchange current during cardiac action potential in ventricular myocytes [J] . BanyaszT., HorvathB., JianZ., Heart rhythm: the official journal of the Heart Rhythm Society . 2012,第1期

机译：心室肌细胞心脏动作电位期间L型Ca 2+电流和Na + / Ca 2+交换电流的分布
4. Electrophysiological Effects of SN-6, a Novel Na~+/Ca~(2+) Exchange Inhibitor on Membrane Currents in Guinea Pig Ventricular Myocytes [C] . CHUN-FENG NIU, YASUHIDE WATANABE, TAKAHIRO IWAMOTO, International Conference on Na/Ca Exchange . 2007

机译：SN-6，一种新型NA〜+ / Ca〜（2+）交换抑制剂在豚鼠心室肌细胞膜电流上的电生理效应
5. Sodium(+) affinity and relation to transport kinetics of sodium(2+)/calcium(2+)-potassium(+) exchanger NCKX2. [D] . Altimimi, Haider F. 2009

机译：钠（+）亲和力及其与钠（2 +）/钙（2 +）-钾（+）交换剂NCKX2的传输动力学的关系。
6. Gradation of Ca(2+)-induced Ca2+ release by voltage-clamp pulse duration in potentiated guinea-pig ventricular myocytes. [O] . G Isenberg, S Han 1994

机译：Ca（2+）诱导的Ca2 +释放的分级在增强的豚鼠心室肌细胞中的电压钳脉冲持续时间。
7. Profile of L-type Ca(2+) current and Na(+)/Ca(2+) exchange current during cardiac action potential in ventricular myocytes [O] . Bányász, Tamás, Horváth, Balázs, Jian, Zhong, 2017

机译：心室肌细胞心脏动作电位期间L型Ca（2+）电流和Na（+）/ Ca（2+）交换电流的分布

Class Ⅲ anti-arrhythmia drug E-4031 potentiates Na~2+/Ca~2+ exchange current in rat ventricular myocytes

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