Influence of tramadol on morphine discriminative behavior in rats

Ren Yan-Hua; Zheng Ji-Wang

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Influence of tramadol on morphine discriminative behavior in rats

机译：曲马多对大鼠吗啡判别行为的影响

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Tramadol fully substituted morphine at a dose of 32 mg/kg or higher. The ED_50 value of the discriminative effects of tramodol was 20.94 mg/kg, higher than that of morphine(2.04 mg/kg, P < 0.01). MA failed to generalize to tramadol at the doses tested. Naltrexone antagnized the discriminative respondse of tramadol. Tramadol can Substitute for morphine in morphine discriminative rats. The discriminative stimulus effects of tranmadol are medi- Ated by a mu opioid mechanism.

机译：曲马多完全取代的吗啡剂量为32 mg / kg或更高。曲美多的辨别作用的ED_50值为20.94 mg / kg，高于吗啡（2.04 mg / kg，P <0.01）。 MA未能以所测试的剂量推广到曲马多。纳曲酮使曲马多具有歧视性。曲马多可以替代吗啡有区别的大鼠中的吗啡。穆达阿片机制可有效地调节曲马多的区别性刺激作用。

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《Acta Pharmacologica Sinica》 |2000年第10期|p.924-926|共3页
作者
Ren Yan-Hua; Zheng Ji-Wang;
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正文语种 eng
中图分类药理学;
关键词
tramadol; dependency(psychology); discrimination(psychology);

机译：曲马多依赖（心理学）;歧视（心理学）;

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Influence of tramadol on morphine discriminative behavior in rats

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