Prophylactic effect of methylene blue against neurotoxicity of sodium nitroprusside

Wang Yu-Xia; Sun Jun; Sun Man-Ji

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Prophylactic effect of methylene blue against neurotoxicity of sodium nitroprusside

机译：亚甲蓝对硝普钠钠神经毒性的预防作用

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AIM: To examine the effect of methylene blue (MB) on cytotoxicities of sodium nitroprusside (SNP) and cyclic guanosine monophosphate (cGMP) in cultivated cerebellar neurons. CONCLUSION: SNP and cGMP inhibit The vitality of murine neurons in vitro. MB Injection ICV markedly antagonizes the dose- Dependent neuron-toxic effect of SNP in respect Of convulsion and mortality of mice.

机译：目的：研究亚甲基蓝（MB）对硝普钠（SNP）和环状鸟苷单磷酸（cGMP）在培养的小脑神经元中的细胞毒性的作用。结论：SNP和cGMP在体外抑制鼠神经元的活力。 MB注射ICV在小鼠惊厥和死亡率方面明显拮抗SNP的剂量依赖性神经元毒性作用。

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《Acta Pharmacologica Sinica》 |1999年第2期|p.185-187|共3页
作者
Wang Yu-Xia; Sun Jun; Sun Man-Ji;
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正文语种 eng
中图分类药理学;
关键词
nitroprusside; methylene blue; nitric oxide;

机译：硝普钠;亚甲蓝;一氧化氮;

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4. Screening Factors Influencing Adsorption of Methylene Blue Aqueous Solution Onto Immobilized Glycerine Pitch/Sodium Alginate Beads [C] . Amir Asyraf Nasarudin, Norzita Ngadi, Noorhalieza Ali, International Conference on Separation Technology . 2020

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5. Cost-effectiveness of intravenous nicardipine versus sodium nitroprusside for postoperative hypertension after cardiac surgery. [D] . Barnes, Brian Joseph. 2010

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6. Comparison of two soluble guanylyl cyclase inhibitors methylene blue and ODQ on sodium nitroprusside-induced relaxation in guinea-pig trachea [O] . Tsong-Long Hwang, Chin-Chung Wu, Che-Ming Teng 1998

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8. Production of Methylene Blue and Sodium Fluorescein Aerosols with the May Spinning Top Aerosol Generator [R] . Mitchell, J. P., Ramsey, C. A. 1982

机译：用旋转顶部气溶胶发生器生产亚甲基蓝和荧光素钠气溶胶

Prophylactic effect of methylene blue against neurotoxicity of sodium nitroprusside

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