Pharmacological regulation of striatal gene expression by metabotropic glutamate receptors

John Qiang Wang; Li-Min Mao

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Pharmacological regulation of striatal gene expression by metabotropic glutamate receptors

机译：代谢型谷氨酸受体调节纹状体基因表达的药理作用

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摘要

Metabotropic glutamate receptors (mGluR) are densely expressed by striatal medium spiny neurons. Activation of mGluR in this brain region alters local Transmitter release and behaviors of experimental Animals. In particular, mGluR regulate transcription Factor and neuropeptide gene expression in striatal Neurons through their connections with multiple Intracellular effectors.

机译：代谢型谷氨酸受体（mGluR）由纹状体中棘神经元密集表达。在此大脑区域中的mGluR的激活改变了局部递质的释放和实验动物的行为。尤其是，mGluR通过与多个细胞内效应子的连接来调节纹状体神经元中的转录因子和神经肽基因表达。

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《Acta Pharmacologica Sinica》 |1999年第7期|p.577-584|共8页
作者
John Qiang Wang; Li-Min Mao;
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正文语种 eng
中图分类药理学;
关键词
excitatory amino acids; dopamine; immediate-early genes;

机译：兴奋性氨基酸;多巴胺立即早期基因;

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专利

1. Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective allosteric metabotropic glutamate receptor 1 antagonist, FTIDC [4-[1-(2-fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide]. [J] . Satow A, Maehara S, Ise S, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2008,第2期

机译：代谢型谷氨酸受体1拮抗剂与代谢型谷氨酸受体5拮抗剂和代谢型谷氨酸受体2/3激动剂在啮齿类动物中的药理作用：选择性变构代谢型谷氨酸受体1拮抗剂FTIDC的详细研究[4- [1-（ [2-氟吡啶-3-基）-5-甲基-1H-1,2,3-三唑-4-基] -N-异丙基-N-甲基-3,6-二氢吡啶-1（2H）-羧酰胺]。
2. The role of metabotropic glutamate receptors in regulation of striatal proenkephalin expression: implications for the therapy of Parkinson's disease. [J] . Wardas J, Pietraszek M, Wolfarth S, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2003,第3期

机译：代谢型谷氨酸受体在调节纹状体前脑啡肽表达中的作用：对帕金森氏病的治疗意义。
3. Activation of Intracellular Metabotropic Glutamate Receptor 5 in Striatal Neurons Leads to Up-regulation of Genes Associated with Sustained Synaptic Transmission Including Arc/Arg3.1 Protein [J] . Vikas Kumar, Paul Fahey, Yuh-Jiin I. Jong, The Journal of biological chemistry . 2012,第8期

机译：在纹状体神经元中的细胞内代购谷氨酸受体5的活化导致与持续突触传递相关的基因的上调，包括弧/ arg3.1蛋白
4. Regulation of Adrenoceptor and MuscarinicReceptor Gene Expression after Single andRepeated Stress [C] . Jaromir Myslivecek, Andrej Tillinger, Martina Novakova, International Symposium on Catecholamines and Other Neurotransmitters in Stress . 2008

机译：肾上腺素依赖者和肌肉内菌的调节单肾上腺素胁迫后的基因表达
5. Functional analysis of the effects of striatal metabotropic glutamate receptor stimulation. [D] . Kearney, Jennifer Ann. 1997

机译：纹状体代谢型谷氨酸受体刺激作用的功能分析。
6. Activation of Intracellular Metabotropic Glutamate Receptor 5 in Striatal Neurons Leads to Up-regulation of Genes Associated with Sustained Synaptic Transmission Including Arc/Arg3.1 Protein [O] . Vikas Kumar, Paul G. Fahey, Yuh-Jiin I. Jong, 2012

机译：纹状体神经元细胞内代谢型谷氨酸受体5的激活导致与持续的突触传递相关的基因（包括Arc / Arg3.1蛋白）的上调。
7. Synergic action of EphB receptors and group-I metabotropic glutamate receptors in modulating spine morphogenesis and the expression of synaptic markers in cultured striatal neurons [O] . CALO' L, PATANE M, SCHILLACI D, 2008

机译：EphB受体和I型代谢型谷氨酸受体在调节纹状体神经元中脊柱形态发生和突触标记物表达中的协同作用

Pharmacological regulation of striatal gene expression by metabotropic glutamate receptors

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