Correlation between cytochrome P-450 CYP2D6 (CYP2D6)

Chen Shu-Qing; Peter J Wedlund

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Correlation between cytochrome P-450 CYP2D6 (CYP2D6)

机译：细胞色素P-450 CYP2D6（CYP2D6）之间的相关性

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AIM: To study the correlation between CYP2D6 genotype and its phenotype. MTHODS: CYP2D6 genotyping was made by detecting CYP2D6*3, *4, *6, and *7 alleles with an allele-specific polymerase chain reaction procedure. RESULTS: The CYP2D6 genotypes were well correlated with its phenotypes in all 125 extensive metabolizers and in 43 poor metabolizers. CONCLUSION: Genotype could be used to screen variations of CYP2D6 expression.

机译：目的：研究CYP2D6基因型与其表型的相关性。 MTHODS：通过使用等位基因特异性聚合酶链反应程序检测CYP2D6 * 3，* 4，* 6和* 7个等位基因，进行CYP2D6基因分型。结果：CYP2D6基因型在所有125种广泛代谢者和43种弱代谢者中均与其表型密切相关。结论：基因型可用于筛选CYP2D6表达的变异。

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《Acta Pharmacologica Sinica》 |1999年第7期|p.585-588|共4页
作者
Chen Shu-Qing; Peter J Wedlund;
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正文语种 eng
中图分类药理学;
关键词
cytochrome P-450 CYP2D6; genotype; phenotype;

机译：细胞色素P-450 CYP2D6;基因型;表型;

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Correlation between cytochrome P-450 CYP2D6 (CYP2D6)

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