R-dl-Verapamil downmodulates multidrug resistance of KBv200 cells to vincristine and doxorubicin

Fang Gang; Yang Yu-Long; Li Jie-Shou

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R-dl-Verapamil downmodulates multidrug resistance of KBv200 cells to vincristine and doxorubicin

机译：R-dl-维拉帕米可下调KBv200细胞对长春新碱和阿霉素的多药耐药性

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AIM: To study the attenuation of multidrug resistance (MDR) by R-dl-verapamil (R-Ver) and the acute animal toxicity of R-Ver, and to compare these results of R-Ver with the resutls of dl-verapamil (Ver). METHODS: Cytotoxicity was determined by Tetraxolium (MTT) assay. Cellular accumulation of Doxorubicin (Dox) was measured by fluorescence Spectrophotometry. Acute animal toxicity was tested By ip drug administration in BALB/c mice. CONCLUSION: R-Ver downmodulated the MDR to VCR And Dox at 1.25 μmol·L~-1, and this effect on VCR Can be realized with drug exposure duration of 24 h.

机译：目的：研究R-dl-维拉帕米（R-Ver）对多药耐药性（MDR）的减弱和R-Ver的急性动物毒性，并将R-Ver的这些结果与dl-维拉帕米的结果进行比较（版本）。方法：采用四氧噻唑（MTT）法测定细胞毒性。通过荧光分光光度法测量阿霉素（Dox）的细胞积累。通过在BALB / c小鼠中腹膜内给药来测试急性动物毒性。结论：R-Ver以1.25μmol·L〜-1将MDR下调为VCR和Dox，药物暴露时间为24 h即可实现对VCR的作用。

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《Acta Pharmacologica Sinica》 |1999年第7期|p.647-650|共4页
作者
Fang Gang; Yang Yu-Long; Li Jie-Shou;
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正文语种 eng
中图分类药理学;
关键词
verapamil; vincristine; doxorubicin;

机译：维拉帕米长春新碱阿霉素;

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专利

1. L1210 cells cultivated under the selection pressure of doxorubicin or vincristine express common mechanisms of multidrug resistance based on the overexpression of P-glycoprotein. [J] . Bohacova V, Sulova Z, Dovinova I, Toxicology in vitro: an international journal published in association with BIBRA . 2006,第8期

机译：在阿霉素或长春新碱的选择压力下培养的L1210细胞基于P-糖蛋白的过表达而表达多药耐药的共同机制。
2. A phase II study of the safety and efficacy of the multidrug resistance inhibitor VX-710 combined with doxorubicin and vincristine in patients with recurrent small cell lung cancer. [J] . Gandhi L, Harding MW, Neubauer M, Cancer: A Journal of the American Cancer Society . 2007,第5期

机译：II期研究了多药耐药抑制剂VX-710联合阿霉素和长春新碱在复发性小细胞肺癌患者中的安全性和有效性。
3. The multidrug resistant modulator HZ08 reverses multidrug resistance via P-glycoprotein inhibition and apoptosis sensitization in human epidermoid carcinoma cell line KBv200 [J] . ZhuY.-L., CenJ., ZhangY.-Y., Arzneimittel-Forschung: =Drug Research . 2012,第5期

机译：多药耐药性调节剂HZ08通过抑制人表皮样癌细胞系KBv200中的P-糖蛋白抑制和细胞凋亡敏化作用来逆转多药耐药性
4. Ganoderic Acid Restores the Sensitivity of Multidrug Resistance Cancer Cells to Doxorubicin [C] . Ouyang Jingjing, Wang Yuqiang, Wen Tang International Conference on Materials and Products Manufacturing Technology . 2014

机译：Ganoderic酸恢复多药耐药性癌细胞对多柔比星的敏感性
5. The pharmacokinetic analysis of a therapeutic drug interaction between a type-1 multidrug resistance modulator, valspodar (PSC 833), and an anticancer agent, doxorubicin, in patients. [D] . Naik, George Oliver Archibald. 2005

机译：对患者的1型多药抗性调节剂valspodar（PSC 833）和抗癌药阿霉素之间的治疗药物相互作用的药代动力学分析。
6. Effect of glucose transport inhibitors on vincristine efflux in multidrug-resistant murine erythroleukaemia cells overexpressing the multidrug resistance-associated protein (MRP) and two glucose transport proteins GLUT1 and GLUT3. [O] . R. L. Martell, C. A. Slapak, S. B. Levy 1997

机译：葡萄糖转运抑制剂对多药耐药的鼠红白血病细胞中长春新碱外流的影响该细胞过表达多药耐药相关蛋白（MRP）和两种葡萄糖转运蛋白GLUT1和GLUT3。
7. Effect of glucose transport inhibitors on vincristine efflux in multidrug-resistant murine erythroleukaemia cells overexpressing the multidrug resistance-associated protein (MRP) and two glucose transport proteins, GLUT1 and GLUT3. [O] . Martell, R. L., Slapak, C. A., Levy, S. B. 1997

机译：葡萄糖转运抑制剂对多药耐药的鼠红白血病细胞中长春新碱外流的影响，该细胞过表达多药耐药相关蛋白（MRP）和两种葡萄糖转运蛋白GLUT1和GLUT3。

R-dl-Verapamil downmodulates multidrug resistance of KBv200 cells to vincristine and doxorubicin

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