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首页> 外文期刊>Acta Pharmacologica Sinica >dl-3-n-Butylphthalide attenuates reperfusion-induced blood- brain barrier damage after focal cerebral ischemia in rats
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dl-3-n-Butylphthalide attenuates reperfusion-induced blood- brain barrier damage after focal cerebral ischemia in rats

机译：dl-3-n-丁基苯酞可减轻大鼠局灶性脑缺血后再灌注所致的血脑屏障损害

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摘要

AIM: To study the protective effect of dl-3-n- butylphthalide (NBP) on blood-brain barrier (BBB) damage induced by reperfusion following focal cerebral ischemia. METHODS: Focal cerebral ischemia in rats was performed by inserting a nylon suture into intracranial segment of internal carotid artery to block the origin of middle cerebral artery and reperfusion by withdrawing the nylon suture. Permeability of BBB was determined by extravasation of the protein-bound Evans blue dye to cerebral cortex and further evaluated By immunohistochemical or electronmicroscopic me- Thod. CONCLUSION: NBP has Protective effect on BBB damage induced by reperfusion After MCAO.
机译：目的：研究dl-3-正丁基酞（NBP）对局灶性脑缺血再灌注所致的血脑屏障（BBB）损伤的保护作用。方法：将尼龙缝线插入颈内动脉颅内段，阻断大脑中动脉的起源，并通过撤回尼龙缝线进行再灌注，进行大鼠局灶性脑缺血。通过结合蛋白的伊文思蓝染料向大脑皮层的渗透来确定血脑屏障的通透性，并通过免疫组织化学或电镜方法进行进一步评估。结论：NBP对MCAO后再灌注引起的血脑屏障损害具有保护作用。

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