Effects of tetrandrine on changes of NMDA receptor channel in cortical neurons of rat induced by anoxia

Wang Zhong-Feng; Xue Chun-Sheng; Zhou Qi-Xin

首页> 外文期刊>Acta Pharmacologica Sinica >Effects of tetrandrine on changes of NMDA receptor channel in cortical neurons of rat induced by anoxia

【24h】

Effects of tetrandrine on changes of NMDA receptor channel in cortical neurons of rat induced by anoxia

机译：粉防己碱对缺氧诱导大鼠皮质神经元NMDA受体通道变化的影响。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

AIM: To study the effects of tetrandrine (Tet) on the changes of NMDA receptor channels in cortical neurons induced by anoxia. METHODS: Cell-attached configuration of patch-clamp techniques. Anoxia was produced by perfused cells with 95 /100 N_2 + 5 /100 CO_2 gassed bath solution. RESULTS During anoxia, the open time constant (τ_2), open probability (P_o) of 35- pS and 100-pS channels increased. CONCLUSION: Tet inhibition of the open of NMDA receptor channels Induced by anoxia was one of its protective Mechanism.

机译：目的：研究粉防己碱（Tet）对缺氧诱导的皮质神经元NMDA受体通道变化的影响。方法：膜片钳技术的细胞附着配置。用95/100 N_2 + 5/100 CO_2充气浴溶液灌注细胞会产生缺氧。结果在缺氧期间，35-pS和100-pS通道的开放时间常数（τ_2），开放概率（P_o）增加。结论：Tet抑制缺氧诱导的NMDA受体通道开放是其保护机制之一。

著录项

来源
《Acta Pharmacologica Sinica》 |1999年第8期|p.729-732|共4页
作者
Wang Zhong-Feng; Xue Chun-Sheng; Zhou Qi-Xin;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
tetrandrine; N-methyl-D-aspartate receptors; ion channels;

机译：粉防己碱N-甲基-D-天冬氨酸受体;离子通道;

相似文献

外文文献
中文文献
专利

1. Inhibitory effects of clofilium on membrane currents associated with Ca channels, NMDA receptor channels and Na+, K+-ATPase in cortical neurons. [J] . Yang A, Wang XQ, Sun CS, Pharmacology: International Journal of Experimental and Clinical Pharmacology . 2005,第3期

机译：clofilium对皮质神经元中与Ca通道，NMDA受体通道和Na +，K + -ATPase相关的膜电流的抑制作用。
2. Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons. [J] . Pamenter ME, Shin DS, Buck LT Brain research . 2008,第0期

机译：腺皮质A1受体激活在常氧过程中以百日咳毒素敏感的方式介导NMDA受体的活性，但在海龟皮层神经元中却没有缺氧。
3. Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons. [J] . Pamenter ME, Shin DS, Buck LT Brain research . 2008,第Null期

机译：腺皮质A1受体激活在常氧过程中以百日咳毒素敏感的方式介导NMDA受体的活性，但在海龟皮层神经元中却没有缺氧。
4. EFFECTS OF NMDA AND NON-NMDA RECEPTORS ANTAGONISTS ON THE BEHAVIOR OF CULTURED CORTICAL NETWORKS [C] . Laura Bonzano, Marco Bove, Sergio Martinoia Brain Inspired Cognitive Systems . 2004

机译：NMDA和非NMDA受体对拮抗剂对培养皮质网络行为的影响
5. Effects of voluntary exercise and NMDA receptor subunit selective antagonists on levodopa-induced motor response complications in hemiparkinsonian rats. [D] . Wessell, Ryan H. 2006

机译：自愿运动和NMDA受体亚基选择性拮抗剂对左帕金森病大鼠左旋多巴诱发的运动反应并发症的影响。
6. The blockade of NMDA receptor ion channels by ketamine is enhanced in developing rat cortical neurons [O] . Jianhui Jin, Kerui Gong, Xiaoju Zou, -1

机译：在显影大鼠皮质神经元中通过氯胺酮阻断NMDA受体离子通道的阻断
7. Voltage-dependent interaction of open-channel blocking molecules with gating of NMDA receptors in rat cortical neurons. [O] . Antonov, S M, Johnson, J W 1996

机译：大鼠皮层神经元中开路阻断分子与NMDA受体门控的电压依赖性相互作用。

Effects of tetrandrine on changes of NMDA receptor channel in cortical neurons of rat induced by anoxia

摘要

著录项

相似文献

相关主题

期刊订阅