Antagonistic effects of melatonin on glutamate release and neurotoxicity in cerebral cortex

Zhang Qing-Zhu; Gong Yue-Song; Zhang Jun-Tian

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Antagonistic effects of melatonin on glutamate release and neurotoxicity in cerebral cortex

机译：褪黑激素对大脑皮质谷氨酸释放和神经毒性的拮抗作用

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AIM: To observe the effects of melatonin (Mel) on glutamate (Glu) release from the cortical synaptosomes in old mice and on neurotoxicity induced by KCl, Glu in cultured cortical cells of fetal rat and to explore the antiaging mechanism of Mel. METHODS: Glu release by the synaptosomes in old mouse cerebral cortex was detected in a spectrofluorophotometer. CONCLUSION: The inhibitory Effect of Mel on Glu release from cortical synaptosome And the protective effect of Mel on cortical neurons Against neurotoxicity are its antiaging mechanisms.

机译：目的：观察褪黑激素（Mel）对老龄小鼠皮质突触体谷氨酸（Glu）释放的影响，以及KCl，Glu对胎鼠培养的皮质细胞神经毒性的影响，探讨Mel的抗衰老机制。方法：用荧光分光光度计检测老年小鼠大脑皮层突触小体释放的Glu。结论：Mel对皮质突触小体释放Glu的抑制作用以及Mel对皮层神经元的抗神经毒性的保护作用是其抗衰老的机制。

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《Acta Pharmacologica Sinica》 |1999年第9期|p.829-834|共6页
作者
Zhang Qing-Zhu; Gong Yue-Song; Zhang Jun-Tian;
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正文语种 eng
中图分类药理学;
关键词
melatonin; glutamic acid; neurotoxins;

机译：褪黑激素谷氨酸;神经毒素;

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1. Effects of methylmalonic and propionic acids on glutamate uptake by synaptosomes and synaptic vesicles and on glutamate release by synaptosomes from cerebral cortex of rats. [J] . Brusque AM, Rotta LN, Tavares RG, Brain research . 2001,第1a2期

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2. In Vivo Neuroprotective Effects of Peripheral Kynurenine on Acute Neurotoxicity Induced by Glutamate in Rat Cerebral Cortex [J] . Alok Kumar, G. Nagesh Babu Neurochemical Research . 2010,第4期

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4. Conformal ceramic electrodes that record glutamate release and corresponding neural activity in primate prefrontal cortex [C] . Hampson Robert E., Fuqua Joshua L., Huettl Peter F., . 2013

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6. Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture [O] . PA Rosenberg, S Amin, M Leitner 1992

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8. Peroxide Effects on (3 sup H)L-Glutamate Release by Synaptosomes Isolated fromthe Cerebral Cortex [R] . Gilman, S. C., Bonner, M. J., Pellmar, T. C. 1992

机译：过氧化物对从大脑皮层分离的突触体释放（3 sup H）L-谷氨酸的影响

Antagonistic effects of melatonin on glutamate release and neurotoxicity in cerebral cortex

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