Effects of intra-hippocampal injection of interleukin-2 on pain threshold and formaldhyde-induced substance P-like immunoreactivity in periaqueductal gray and spinal cord

Wu Xuan; Li Hai-Di; Li Xi-Cheng

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Effects of intra-hippocampal injection of interleukin-2 on pain threshold and formaldhyde-induced substance P-like immunoreactivity in periaqueductal gray and spinal cord

机译：海马内注射白介素2对导管周围灰质和脊髓疼痛阈值和甲醛引起的P样物质免疫反应的影响

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AIM: To study the effects of intra-hippocampal injection of interleukin-2 (IL-2) on the substance P-like immunoreactivity (SP-LI) in both periaqueductal gray (PAG) and spinal cord, and on pain threshold in rats. METHDOS: Immunohistochemistry technique was Used and the paw withdrawal threshold to radiant heat Was measured. CONCLUSION: The analgesic Effects of intra-hippocampal injection of IL-2 are Mediated, possible, via the increase of SP in PAG and The decrease of SP in the spinal cord. There is a Synergetic relation between IL-2 and corticotropin.

机译：目的：研究海马内注射白细胞介素2（IL-2）对导水管周围灰质（PAG）和脊髓中P物质免疫反应性（SP-LI）的影响，以及对大鼠疼痛阈值的影响。 METHDOS：使用了免疫组织化学技术，并测量了爪子对辐射热的退缩阈值。结论：可能通过PAG中SP的增加和脊髓中SP的减少来介导海马内注射IL-2的镇痛作用。 IL-2和促肾上腺皮质激素之间存在协同关系。

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《Acta Pharmacologica Sinica》 |1999年第9期|p.839-843|共5页
作者
Wu Xuan; Li Hai-Di; Li Xi-Cheng;
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正文语种 eng
中图分类药理学;
关键词
interleukin-2; substance P; pain threshold;

机译：白介素2;物质P;疼痛阈值;

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1. Effects of intrathecal injection of rapamycin on pain threshold and spinal cord glial activation in rats with neuropathic pain [J] . Lv Jing, Li Zhenci, She Shouzhang, Neurological Research: An Interdisciplinary Quarterly Journal . 2015,第8期

机译：鞘内注射雷帕霉素对神经性疼痛大鼠疼痛阈值和脊髓神经胶质活化的影响
2. Effects of morphine and electroacupuncture on substance P level in spinal cord and their relation to pain threshold in rats [J] . 阮怀珍, 李希成, 黎海蒂中国人民解放军军医大学学报：英文版 . 1993,第001期

机译：吗啡和电针对脊髓含量p水平的影响及其与大鼠疼痛阈值的关系
3. Stimulation of spinal 5-HT(2A/2C) receptors potentiates the capsaicin-induced in vivo release of substance P-like immunoreactivity in the rat dorsal horn. [J] . Kjorsvik Bertelsen A, Warsame Afrah A, Gustafsson H, Brain research . 2003,第1期

机译：脊髓5-HT（2A / 2C）受体的刺激增强了辣椒素诱导的大鼠背角中物质P样免疫反应性的体内释放。
4. A conditional deletion of the GluR2 subunit of the AMPA receptor in adult spinal cord dorsal horn decreases normal sensory thresholds but not injury-induced pain. [D] . Hegarty, Deborah Mary. 2006

机译：成年脊髓背角中AMPA受体的GluR2亚基的有条件删除会降低正常的感觉阈值，但不会导致损伤引起的疼痛。
5. The coexistence of serotonin- and substance P-like immunoreactivity in the spinal cord of the rat as shown by immunofluorescent double labeling [O] . MW Wessendorf, R Elde 1987

机译：免疫荧光双重标记显示大鼠脊髓中血清素和P物质样免疫反应共存
6. Endogenous oxytocin release in periaqueductal gray eases inflammatory pain through long term suppression of pain perception neurons in the spinal cord [O] . M. Iwasaki, A. Charlet 2018

机译：内源性催产素在PeriaqueDuctal灰色中通过长期抑制脊髓中的疼痛感知神经元来缓解炎症疼痛

Effects of intra-hippocampal injection of interleukin-2 on pain threshold and formaldhyde-induced substance P-like immunoreactivity in periaqueductal gray and spinal cord

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