Inhibitory effects of 8-(N-diethylamino)-n-octyl-3,4,5- trimethoxybenzoate (TMB-8) on intracellular Ca~2+ elevated by neurotransmitters in brain cells

Zhang Xiao-Qing; Wang Bing; Zhang Min-Ying

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Inhibitory effects of 8-(N-diethylamino)-n-octyl-3,4,5- trimethoxybenzoate (TMB-8) on intracellular Ca~2+ elevated by neurotransmitters in brain cells

机译：8-（N-二乙氨基）-正辛基-3,4,5-三甲氧基苯甲酸酯（TMB-8）对脑细胞神经递质升高的细胞内Ca〜2 +的抑制作用

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AIM: To study the effects of TMB-8 on [Ca~2+]_i elevation induced by neurotransmitters in dissociated brain cells. METHODS: The brain cell suspension was made using a gentle trituration for 1 min with a polished pipette. The changes of [Ca~2+]_i were detected by the fluorescent indicator, Fura 2-AM. CONCLUSION: TMB-8 inhibited the [Ca~2+]_i Elevation induced by Glu, 5-HT, and His in brain Cells.

机译：目的：研究TMB-8对离体脑细胞神经递质诱导的[Ca〜2 +] _ i升高的影响。方法：用抛光的移液管轻轻研磨1分钟制成脑细胞悬液。用荧光指示剂Fura 2-AM检测[Ca〜2 +] _ i的变化。结论：TMB-8抑制了脑细胞中Glu，5-HT和His诱导的[Ca〜2 +] _ i升高。

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《Acta Pharmacologica Sinica》 |1999年第10期|p.893-896|共4页
作者
Zhang Xiao-Qing; Wang Bing; Zhang Min-Ying;
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正文语种 eng
中图分类药理学;
关键词
brain; cultured cells; nimodipine;

机译：脑;培养细胞尼莫地平;

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1. 8-(N, N-Diethylamino)-n-octyl-3,4,5-trimethoxybenzoate actions on calcium dynamics in cultured vascular smooth muscle cells [J] . Shirley X L LIU, George C Y CHIOU, Zhou CHEN Acta Pharmacologica Sinica . 1997,第1期

机译：8-（N，N-二乙氨基）-正辛基-3,4,5-三甲氧基苯甲酸酯对培养的血管平滑肌细胞中钙动力学的作用
2. Mechanism of inhibitory action of TMB-8 [8-(NN-diethylamino)octyl-3,4,5-trimethoxybenzoate] on aldosterone secretion in adrenal glomerulosa cells [J] . H Rasmussen, I Kojima, K Kojima The biochemical journal . 1985,第1期

机译：TMB-8 [8-（NN-二乙基氨基）辛基-3,4,5-三甲氧基苯甲酸酯]对肾上腺肾小球细胞醛固酮分泌的抑制作用机理
3. Mechanism of inhibitory action of TMB-8 [8-(NN-diethylamino)octyl-3,4,5-trimethoxybenzoate] on aldosterone secretion in adrenal glomerulosa cells [J] . H Rasmussen, I Kojima, K Kojima The biochemical journal . 1985,第1期

机译：TMB-8 [8-（NN-二乙基氨基）辛基-3,4,5-三甲氧基苯甲酸酯]对肾上腺肾小球细胞醛固酮分泌的抑制作用机理
4. The model of glutamate-induced intracellular Ca~(2+) oscillation and intercellular Ca~(2+) wave in brain astrocytes [C] . Isao Goto, Shingo Kinoshita, KiyohisaNatsume Computational Neuroscience Meeting . 2004

机译：谷氨酸细胞内Ca〜（2+）振荡和脑星形胶质细胞中的细胞间Ca〜（2+）波的模型
5. Mechanism of inhibitory action of TMB-8 8-(NN-diethylamino)octyl-345-trimethoxybenzoate on aldosterone secretion in adrenal glomerulosa cells. [O] . I Kojima, K Kojima, H Rasmussen 1985

机译：TMB-8 8-（NN-二乙基氨基）辛基-345-三甲氧基苯甲酸酯对肾上腺肾小球细胞醛固酮分泌的抑制作用机理。
6. Differential allosteric effects of 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate-HCl (TMB-8) on muscarinic receptor subtypes [O] . Gordon Richard K., Chiang Peter K. 1989

机译：8-（N，N-二乙基氨基）辛基-3,4,5-三甲氧基苯甲酸酯-HCl（TMB-8）对毒蕈碱受体亚型的变构作用
7. Differential Allosteric Effects of 8-(n,n-Diethylamine) Octyl-3,4,5-Trimethoxybenzoate-HC1(TMB-8) on Muscarinic Receptor Subtypes. [R] . Gordon, R. K., Chiang, P. K. 1989

机译：8-（n，n-二乙胺）辛基-3,4,5-三甲氧基苯甲酸盐-HCl（TmB-8）对毒蕈碱受体亚型的差异变构效应。

Inhibitory effects of 8-(N-diethylamino)-n-octyl-3,4,5- trimethoxybenzoate (TMB-8) on intracellular Ca~2+ elevated by neurotransmitters in brain cells

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