Pharmacolinetics of intragastric ipriflavone solid dispersion in rats

Li Ya-Ping; Zhou Jian-Jun; Zhang Xian-Ying

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Pharmacolinetics of intragastric ipriflavone solid dispersion in rats

机译：大鼠胃内依普黄酮固体分散体的药代动力学

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AIM: To evaluate pharmacokinetic behavior of ipriflavone solid dispersion in rats. METHODS: the plasma concentrations of ipriflavone in rats were determined by HPLC with UV detector. RESULTS: Plasma concentration-time curves after ig ipriflavone Solid dispersion 250 mg·kg~-1 in rats were fitted with One-compartment model. CONCLUSION: Ipriflavone in solid Dispersion was absorbed more effectively than that in Physical mixture in rats.

机译：目的：评价依普黄酮固体分散体在大鼠体内的药代动力学行为。方法：采用紫外检测器高效液相色谱法测定大鼠血浆中异丙乙酮的含量。结果：ig ipriflavone固体分散体250 mg·kg〜-1在大鼠体内后的血浆浓度-时间曲线符合一室模型。结论：大鼠体内固体分散体中异黄酮的吸收效果优于物理混合物中的异黄酮吸收效果。

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《Acta Pharmacologica Sinica》 |1999年第11期|p.1035-1038|共4页
作者
Li Ya-Ping; Zhou Jian-Jun; Zhang Xian-Ying;
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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
pharmacokinetics; ipriflavone; isoflavones;

机译：药代动力学ipriflavone;异黄酮;

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1. Prepaation and dissolution property of ipriflavone solid dispersion [J] . Li Ya-Ping, Zhang Xian-Yiang, Zhou Jian-Jun Acta Pharmacologica Sinica . 1999,第10期

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2. Solid-liquid equilibrium solubility, thermodynamic properties, solvent effect of Ipriflavone in twelve pure solvents at various temperatures [J] . Huang Zibo, Zun Yuanyuan, Gong Yi, The Journal of Chemical Thermodynamics . 2020,第1期

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3. Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles [J] . Cheng-Feng Luo, Ning Hou, Juan Tian, International Journal of Nanomedicine . 2013,第1期

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4. EFFECTS OF HYDROPHILLIC POLYMERS ON SOLID DISPERSIONS OF IPRIFLAVONE TO IMPROVE BIOAVAILABILITY [C] . H.B. Lee, G. Khang, J. Jeong, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

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Pharmacolinetics of intragastric ipriflavone solid dispersion in rats

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