Properties of transient outward potassium current tan dinward rectifier potassium current in immature human atrial myocytes

Liang Yong; Sun Xiu-Mei; Wang Xiao-Liang

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Properties of transient outward potassium current tan dinward rectifier potassium current in immature human atrial myocytes

机译：未成熟人心房肌细胞瞬时外向钾电流tan dinward整流钾电流的特性

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AIM: To study the properties of transient outward K~+ current (I_to) and inward rectifier K~+ current (I_K1) in immature human heart. METHODS: I_to and I_k1 were recorded using whole-cell patch-clamp technique in atrial myocytes isolated from 12 immature (aged from 6 months to 5 a) human hearts. CONCLUSION: Both I_to and I_k1 are important K~+ channel currents in Immature human atrial myocytes. 4-AP can affect the Inactivation and recovery of I_to at low concentration (0.3 mmol·L~-1) and affect its activation at high concentration (1 mmol·L~-1).

机译：目的：研究未成熟人心脏的瞬时外向K〜+电流（I_to）和内向整流K〜+电流（I_K1）的特性。方法：使用全细胞膜片钳技术在从12个未成熟（6个月至5a年龄）人心脏分离的心房肌细胞中记录I_to和I_k1。结论：I_to和I_k1都是人类未成熟心房肌细胞中重要的K〜+通道电流。 4-AP在低浓度（0.3mmol·L〜-1）下会影响I_to的失活和恢复，在高浓度（1mmol·L〜-1）下会影响I_to的失活和恢复。

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《Acta Pharmacologica Sinica》 |1999年第11期|p.1005-1010|共6页
作者
Liang Yong; Sun Xiu-Mei; Wang Xiao-Liang;
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正文语种 eng
中图分类药理学;
关键词
potassium channels; patch-clamp techniques; heart atrium;

机译：钾通道膜片钳技术;心房;

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1. Properties of the transient outward, ultra-rapid delayed rectifier and acetylcholine-sensitive potassium currents in isolated atrial myocytes from dogs: sinus rhythm and tachypaced model of permanent atrial fibrillation [J] . Zsófia Kohajda, Attila Kristóf, Péter P Kovács, BMC Pharmacology . 2011,第Supplementa2期

机译：狗离体心房肌瞬时向外超快速延迟整流器和乙酰胆碱敏感钾电流的性质：窦性心律和永久性心房颤动的心动过速模型
2. Raloxifene inhibits transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes. [J] . Liu H, Jin MW, Xiang JZ, European Journal of Pharmacology: An International Journal . 2007,第1a3期

机译：雷洛昔芬抑制人心房肌细胞中的瞬时向外和超快速延迟的整流钾电流。
3. Effects of carvedilol on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes. [J] . Deng C, Yu X, Kuang S, Life sciences . 2007,第7期

机译：卡维地洛对人心房肌细胞瞬时向外和超快速延迟整流钾电流的影响。
4. Effects of the transient outward potassium current on action potential upstroke velocities tested using the dynamic clamp technique [C] . Arie O. Verkerk, Christiaan C. Veerman, Jan G. Zegers, Computing in Cardiology Conference . 2016

机译：瞬态向外钾电流对使用动态钳位技术测试的动作电位上冲速度的影响
5. Roles of delayed repolarization and altered calcium handling in determining regional arrhythmia propensity under conditions of reduced inward-rectifier potassium current. [D] . Radwanski, Przemyslaw. 2010

机译：内向整流器钾电流降低的情况下，延迟复极化和改变钙处理在确定区域性心律失常倾向中的作用。
6. Properties of the transient outward ultra-rapid delayed rectifier and acetylcholine-sensitive potassium currents in isolated atrial myocytes from dogs: sinus rhythm and tachypaced model of permanent atrial fibrillation [O] . Zsófia Kohajda, Attila Kristóf, Péter P Kovács, 2011

机译：狗离体心房肌细胞瞬时向外超快速延迟整流器和乙酰胆碱敏感钾电流的特性：窦性心律和永久性心房纤颤的心动过速模型
7. Properties of the transient outward, ultra-rapid delayed rectifier and acetylcholine-sensitive potassium currents in isolated atrial myocytes from dogs: sinus rhythm and tachypaced model of permanent atrial fibrillation [O] . Zsófia Kohajda, Attila Kristóf, Péter P Kovács, 2011

机译：狗离体心房肌细胞瞬时向外超快速延迟整流器和乙酰胆碱敏感钾电流的特性：窦性心律和永久性心房纤颤的心动过速模型
8. Differential Expression of Inward and Outward Potassium Currents in the Macrophage-Like Cell Line J774.1 [R] . Gallin, E. K., Sheehy, P. A. 1985

机译：巨噬细胞样细胞系J774.1中向内和向外钾电流的差异表达

Properties of transient outward potassium current tan dinward rectifier potassium current in immature human atrial myocytes

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