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首页> 外文期刊>Acta Pharmacologica Sinica >Chlorpromazine inhibits hepatocyte apoptosis caused by withdrawal of phenobarbital in mice
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Chlorpromazine inhibits hepatocyte apoptosis caused by withdrawal of phenobarbital in mice

机译：氯丙嗪抑制小鼠苯巴比妥撤药引起的肝细胞凋亡

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AIM: To study the inhibitory effect of chlorpromazine (Chl), verapamil, and aspirin on hepatocyte apoptosis induced by the cessation of phenobarbital (Phe) treatment in mice. METHODS: Liver DNA content, ratio of liver weight/body weight, DNA fragmentation, DNA electrophoresis, the end-labeling test (TUNEL), And the norphologic changes of liver cells as indices of Liver mass and hepatocyte apoptosis were applied to Investigate (1) the kinetic process of hepatocyte Proliferation induced by Phe 75 mg·kg~-1 ip and the Regresion of regression of hyperplastic liver caused by withdrawal of Phe in mice, (2) the effect of Chl 25 mg·kg~-1, Verapamil 50 mg·kg~-1 or aspirin 60 mg·kg~-1 ip on Mouse hepatocyte apoptosis, and (3) the time course of Effects of Chl on the regression of liver size and DNA Fragmentation content after withdrawal of Phe. CONCLUSION: The Ca~2+ -calmodulin played an important role in the Hepatocyte apoptosis caused by withdrawal of Phe.
机译：目的：研究氯丙嗪（Chl），维拉帕米和阿司匹林对停止苯巴比妥（Phe）治疗所致小鼠肝细胞凋亡的抑制作用。方法：采用肝DNA含量，肝重/体重比，DNA片段化，DNA电泳，末端标记试验（TUNEL），以肝细胞的形态学变化作为肝质量和肝细胞凋亡的指标进行研究（1 ）Phe 75 mg·kg〜-1 ip引起的肝细胞增殖的动力学过程和Phe撤离引起的增生性肝退化的回归；（2）Chl 25 mg·kg〜-1，维拉帕米的作用50 mg·kg〜-1 ip或阿司匹林60 mg·kg〜-1 ip对小鼠肝细胞凋亡的影响，以及（3）Chl对撤消Phe后肝脏大小和DNA片段含量降低的影响的时间过程。结论：Ca〜2 +-钙调蛋白在Phe戒断引起的肝细胞凋亡中起重要作用。

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