Effects of RP58866 on transmembrane K~+ current s in mammalian ventricular myocytes

Yang Bao-Feng; Li Gui-Rong; Xu Chang-Qing

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Effects of RP58866 on transmembrane K~+ current s in mammalian ventricular myocytes

机译：RP58866对哺乳动物心室肌细胞跨膜K〜+电流的影响

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AIM: To determine effects of RP58866 on inward rectifier K~+ current (I_k1), transient outward K~+ current (I_to) and delayed outward rectifier K~+ current (I_K) in isolated cardiac myocytes. METHODS: In isolated ventricular myocytes of guinea pig and dog, the effect of RP58866 on I_k1, I_to and I_K were observed by the whole cell voltage-clamp technique. CONCLUSION: RP58866 inhibits I_k1, I_to, and I_K in cardiace myocytes With a similar potency, and is not a specific I_k1 Inhibitor.

机译：目的：确定RP58866对分离的心肌细胞内向整流器K〜+电流（I_k1），瞬态向外K〜+电流（I_to）和延迟向外整流器K〜+电流（I_K）的影响。方法：用全细胞电压钳技术观察豚鼠和狗的离体心室肌细胞中RP58866对I_k1，I_to和I_K的影响。结论：RP58866抑制心脏心肌细胞中的I_k1，I_to和I_K具有相似的效力，并且不是特异性的I_k1抑制剂。

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《Acta Pharmacologica Sinica》 |1999年第11期|p.961-969|共9页
作者
Yang Bao-Feng; Li Gui-Rong; Xu Chang-Qing;
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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
myocardium; cultured cells; patchclamp techniques;

机译：心肌培养细胞膜片钳技术;

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Effects of RP58866 on transmembrane K~+ current s in mammalian ventricular myocytes

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