KN-62 provides neuroprotection against glutamate-induced excitotoxicity in neurons

Gao Can; Zhang Guang-Yi

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KN-62 provides neuroprotection against glutamate-induced excitotoxicity in neurons

机译：KN-62对谷氨酸诱导的神经元兴奋性毒性提供神经保护

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AIM: To study the effects of KN-62, an inhibitor of Ca~2+ -calmodulin dependent protein kinase Ⅱ (CCDPK Ⅱ), on the damage of cortical neurons and mechansims of the loss of CCDPK Ⅱ activity induced by sodium glutamate (Glu). CONCLUSION: KN- 62 provided the protection against excitotoxicity and the loss of CCDPK Ⅱ activity as well as backphosphoryla- tion of endogenous proteins induced by Glu. The neuroprotection provided by KN-62 was due to the inhibition of autophosphorylation of CCDPK Ⅱ.

机译：目的：研究Ca〜2 +-钙调蛋白依赖性蛋白激酶Ⅱ（CCDPKⅡ）抑制剂KN-62对谷氨酸钠（Glu）诱导的皮质神经元损伤和CCDPKⅡ活性丧失的机制。）。结论：KN-62可以防止Glu引起的兴奋性毒性和CCDPKⅡ活性的丧失以及内源蛋白的反磷酸化。 KN-62提供的神经保护作用是由于抑制CCDPKⅡ的自磷酸化。

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《Acta Pharmacologica Sinica》 |1999年第11期|p.991-994|共4页
作者
Gao Can; Zhang Guang-Yi;
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正文语种 eng
中图分类药理学;
关键词
sodium glutamate; Ca~2+ -calmodulin dependent protein kinase; KN-62;

机译：谷氨酸钠Ca〜2 +-钙调蛋白依赖性蛋白激酶;KN-62;

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1. Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models [J] . Xu Daping, Chen Haiyun, Mak Shinghung, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2016,第Null期

机译：T-006，一种新型的四甲基吡嗪多功能衍生物在神经元细胞模型中的抗谷氨酸诱导的兴奋性毒性和神经突生长的神经保护作用
2. L-Lactate-Mediated Neuroprotection against Glutamate-Induced Excitotoxicity Requires ARALAR/AGC1 [J] . Llorente-Folch Irene, Rueda Carlos B., Perez-Liebana Irene, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2016,第16期

机译：L-乳酸介导的对谷氨酸诱导的兴奋性毒性的神经保护作用需要ARALAR / AGC1。
3. Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models [J] . Xu Daping, Chen Haiyun, Mak Shinghung, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2016,第Null期

机译：对谷氨酸诱导的兴奋毒性和T-006的神经保护诱导诱导神经酸诱导，神经细胞模型中四甲基吡嗪的新型多功能衍生物
4. Application of Confocal Microscopy on Glutamate-Induced Intracellular Calcium Transient in Neurons [C] . Geng Zhu, Wei Zhou, Yuan Zhang, Imaging, Manipulation, and Analysis of Biomolecules, Cells and Tissues IV; Progress in Biomedical Optics and Imaging; vol.7 no.11 . 2006

机译：共聚焦显微镜在谷氨酸诱导神经元细胞内钙瞬变中的应用
5. Calcium/CAM dependent protein kinase II (CaMKII) in glutamate-induced neuronal excitotoxicity [D] . Vest, Rebekah Susan 2010

机译：钙/ CAM依赖性蛋白激酶II（CaMKII）在谷氨酸诱导的神经元兴奋性毒性中的作用
6. l-Lactate-Mediated Neuroprotection against Glutamate-Induced Excitotoxicity Requires ARALAR/AGC1 [O] . Irene Llorente-Folch, Carlos B. Rueda, Irene Pérez-Liébana, 2016

机译：乳酸介导的谷氨酸诱导的兴奋性毒性的神经保护需要ARALAR / AGC1。
7. Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models [O] . Xu D, Chen H, Mak S, 2016

机译：T-006，一种新型的四甲基吡嗪多功能衍生物在神经元细胞模型中的抗谷氨酸诱导的兴奋性毒性和神经突生长的神经保护作用

KN-62 provides neuroprotection against glutamate-induced excitotoxicity in neurons

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