Effects of ligustrazine, tanshinone Ⅱ A, ubiquinone, and idebenone on mouse water maze performance

Liu Xiao-Jun; Wu Wu-Tong

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Effects of ligustrazine, tanshinone Ⅱ A, ubiquinone, and idebenone on mouse water maze performance

机译：川gust嗪，丹参酮ⅡA，泛醌和艾地苯醌对小鼠水迷宫性能的影响

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AIM: To observe the effects of four drugs, ligustrazine (Lig), tanshinone Ⅱ A (Tan), ubiquinone (Ubi) and idebenone (Ide), on learning and memory of mouse. METHODS: Mouse water maze was used to evaluate Nootropic effect. RESULTS: In comparison with the Defective model (only scopolamine 3 mg·kg~-1, Tan 20 Mg·kg~-1, ig) shortened the escape latency dramatical- Ly form (36±19) s to (11±5) s (P＜0.01) and Reduced errors from 7±5 to 1.5±1.3 (P＜0.05). CONCLUSION: Tan, Ubi, and Ide improved Scopolamine-caused spatial performance defects in Mouse.

机译：目的：观察川gust嗪（Lig），丹参酮ⅡA（Tan），泛醌（Ubi）和艾地苯醌（Ide）四种药物对小鼠学习和记忆的影响。方法：使用小鼠水迷宫评估促智作用。结果：与缺陷模型相比（仅东pol碱3 mg·kg〜-1，Tan 20 Mg·kg〜-1，ig）将逃逸潜伏期Ly形式（36±19）s缩短为（11±5） s（P ＜0.01），误差从7±5降低到1.5±1.3（P ＜0.05）。结论：Tan，Ubi和Ide改善了东co碱引起的小鼠空间性能缺陷。

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《Acta Pharmacologica Sinica》 |1999年第11期|p.987-990|共4页
作者
Liu Xiao-Jun; Wu Wu-Tong;
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正文语种 eng
中图分类药理学;
关键词
maze learning; ligusrazine; tanshinone Ⅱ A;

机译：迷宫学习ligusrazine;丹参酮ⅡA;

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Effects of ligustrazine, tanshinone Ⅱ A, ubiquinone, and idebenone on mouse water maze performance

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