Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers

Femando Rodriguez de fonseca; Amanda J Roberts; Ainhoa Bilbao

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Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers

机译：大麻素受体拮抗剂SR141716A减少暴露于乙醇-蒸气室的大鼠的有效乙醇自我管理

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AIM: To study the potential role of dependence status on CB_1-mediated blockade of ethanol self-administa- tion. METHODS: We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg ) on operant ethanol (10 /100 v/v) self- administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers. CONCLUSION: These results further support that cannabinoid CB_1 receptor blockade may have a potential utility for The treatment of alcoholism.

机译：目的：研究依赖状态对CB_1介导的乙醇自我管理阻断的潜在作用。方法：我们研究了大麻素拮抗剂SR141716A（0、0.03、0.3和3 mg / kg）对雄性Wistar大鼠慢性酒精依赖型操作性乙醇（10/100 v / v）自我给药的影响（14d）暴露于乙醇蒸气室或暴露于相同蒸气室中的空气。结论：这些结果进一步支持大麻素CB_1受体阻滞剂可能具有治疗酒精中毒的潜在效用。

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《Acta Pharmacologica Sinica》 |1999年第12期|p.1109-1114|共6页
作者
Femando Rodriguez de fonseca; Amanda J Roberts; Ainhoa Bilbao;
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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
ethanol; self administration; cannabinoid receptors;

机译：乙醇自我管理;大麻素受体;

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专利

1. Functional consequences of the acute administration of the cannabinoid receptor antagonist, SR141716A, in cannabinoid-naive and -tolerant animals: a quantitative 2-(14C)deoxyglucose study. [J] . Freedland CS, Whitlow CT, Smith HR, Brain research . 2003,第1a2期

机译：初次使用大麻素和耐受性动物对大麻素受体拮抗剂SR141716A的急性给药的功能后果：定量2-（14C）脱氧葡萄糖研究。
2. The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. [J] . Schroeder JP, Overstreet DH, Hodge CW Psychopharmacology . 2005,第1期

机译：mGluR5拮抗剂MPEP会在维持酒精期间（P）大鼠中，在维持期间以及反复酒精剥夺后，降低有效乙醇的自我施用。
3. The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats [J] . Jason P. Schroeder, David H. Overstreet, Clyde W. Hodge Psychopharmacology . 2005,第1期

机译：mGluR5拮抗剂MPEP降低了在偏爱酒精（P）的大鼠在维持过程中以及反复酒精剥夺后的有效乙醇自我管理
4. l-stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates methamphetamine self-administration in rate [C] . Kai Yue, BaoMiao Ma, JunQiao Xing International Conference on Applied Sciences, Engineering and Technology . 2014

机译：L- StepHolidine，天然存在的多巴胺D1受体激动剂和D2受体拮抗剂，衰减甲基苯丙胺自我管理
5. Administration of a Cannabinoid Receptor Antagonist Following Chronic Delta9-Tetrahydrocannabinol Induces Physical Withdrawal in the Absence of a Dysphoric State. [D] . Ford, Brittany. 2010

机译：慢性Delta9-四氢大麻酚对大麻素受体拮抗剂的管理在缺乏兴奋状态的情况下会导致身体退缩。
6. A Novel Brain Penetrant NPS Receptor Antagonist NCGC00185684 Blocks Alcohol-Induced ERK-Phosphorylation in the Central Amygdala and Decreases Operant Alcohol Self-Administration in Rats [O] . Annika Thorsell, Jenica D. Tapocik, Ke Liu, 2013

机译：新型脑渗透性NPS受体拮抗剂NCGC00185684阻断中枢杏仁核中酒精诱导的ERK磷酸化并降低大鼠中操作性酒精的自我管理。
7. A Novel Brain Penetrant NPS Receptor Antagonist, NCGC00185684, Blocks Alcohol-Induced ERK-Phosphorylation in the Central Amygdala and Decreases Operant Alcohol Self-Administration in Rats [O] . Thorsell, Annika, Tapocik, Jenica D, Liu, Ke, 2013

机译：新型脑渗透性NPS受体拮抗剂NCGC00185684可以阻止酒精引起的杏仁核中枢ERK磷酸化，并降低大鼠中操作性酒精的自我管理。

Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers

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