Involvement of a putative G-protein-coupled receptor and a branching pathway in argipressin(4-8)signal transduction in rat hippocampus

Qiao-Li Ya; Du Yu-Cang

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Involvement of a putative G-protein-coupled receptor and a branching pathway in argipressin(4-8)signal transduction in rat hippocampus

机译：假定的G蛋白偶联受体和分支途径参与大鼠海马中的ar加压素（4-8）信号转导。

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Conclusion: AVP_4-8 stimulated signal transduction via a GPCR and a branching pathway in rat hippocampus. AIM: To study the signal transduction pathway Induced by argipressin(4-8)(AVP_4-8)in rat Hippocampus. METHODS: Rat hippocampi were Sectioned transversely at 300μm with a tissue chopper And transferred to fresh incubation solution circulated With a humidified gas mixture of 95/100 O_2+5/100 CO_2 At 36±0.5 deg. C. after incubation with various drugs, MAP kinase(MAPK)activity and CA~2+/calmodulin- Dependent protein kinaseⅡ(CaMKⅡ)autophos- Phorylation were measured.

机译：结论：AVP_4-8通过GPCR和分支通路刺激大鼠海马信号转导。目的：研究阿霉素加压素（4-8）（AVP_4-8）在大鼠海马中的信号转导途径。方法：用组织切碎器将大鼠海马以300μm的横截面横向切开，并转移至新鲜的培养液中，该培养液在95±100o_2 + 5/100±CO_2加湿的混合气体中在36±0.5度下循环。与多种药物孵育后，测定了MAP激酶（MAPK）活性和CA〜2 + /钙调蛋白依赖性蛋白激酶Ⅱ（CaMKⅡ）自磷酸化。

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《Acta Pharmacologica Sinica》 |1998年第1期|p.15-20|共6页
作者
Qiao-Li Ya; Du Yu-Cang;
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正文语种 eng
中图分类药理学;
关键词
argipressin; vasopressins; G-proteins; vasopressin receptors;

机译：阿霉素加压素血管加压素;G蛋白血管加压素受体;

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Involvement of a putative G-protein-coupled receptor and a branching pathway in argipressin(4-8)signal transduction in rat hippocampus

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