Pinacidil suppression on 5-HT_3 receptor-mediated contraction of guinea pig ileum in vitro

Yuan Yu-Min; Xu De-Yi; Hu Guo_Yuan

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Pinacidil suppression on 5-HT_3 receptor-mediated contraction of guinea pig ileum in vitro

机译：吡那地尔对5-HT_3受体介导的豚鼠回肠收缩的抑制作用

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Conclusion: The inhibition by pinacidil of 5-HT_3 receptor-mediated GPI contractile responses may be mediated through activation of ATP- sensitive K~+ channels located in preunctional myenteric neurons. Aim: To study the effects of the K~+ channel opener Pinacidil on 5-HT_3 receptor-mediated contractions of The isolated guinea pig ileum(GPI)longitudinal Muscle-myenteric plexus strip preparations. Methods: GPI contractions were recorded with a Chart recorder through isometric transducers.

机译：结论：吡那地尔对5-HT_3受体介导的GPI收缩反应的抑制作用可能是通过激活位于预期的肠系膜神经元中的ATP敏感性K〜+通道而实现的。目的：研究K〜+通道开放剂吡那地尔对5-HT_3受体介导的豚鼠回肠（GPI）纵向肌-肌丛丛制剂的收缩的影响。方法：GPI收缩是通过等距传感器用Chart记录仪记录的。

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《Acta Pharmacologica Sinica》 |1998年第1期|p.31-35|共5页
作者
Yuan Yu-Min; Xu De-Yi; Hu Guo_Yuan;
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正文语种 eng
中图分类药理学;
关键词
serotonin receptors; pinacidil; ileum; myenteric plexus;

机译：血清素受体;吡那地尔;回肠肠神经丛;

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1. Tetraethylammonium and 4-aminopyridine enhancement of 5-HT_3 receptor-mediated contraction of guinea pig illeum in vitro [J] . Yuan Yu-Min, Yang Hui-Hua, Hu Guo-Yuan Acta Pharmacologica Sinica . 1998,第5期

机译：四乙铵和4-氨基吡啶增强5-HT_3受体介导的豚鼠回肠收缩的体外作用
2. Inhibition of native 5-HT_3 receptor-evoked contractions in guinea pig and mouse ileum by antimalarial drugs [J] . Stephen P. Kelley, Jacqueline Walsh, Mark C. Kelly, European Journal of Pharmacology: An International Journal . 2014,第Null期

机译：抗疟药对豚鼠和小鼠回肠天然5-HT_3受体引起的收缩的抑制作用
3. Desensitization of depolarization-mediated contractile pathways does not necessarily regulate receptor-mediated excitation-contraction coupling in longitudinal smooth muscle of guinea pig ileum [J] . HishinumaS., ShojiM. Clinical and experimental pharmacology & physiology . 2011,第4期

机译：去极化介导的收缩途径的脱敏并不一定调节豚鼠回肠纵向平滑肌中受体介导的兴奋-收缩偶联。
4. Influence of noise on spontaneous contractions of tensor tympani muscle of guinea pig [C] . Ernst J. Haberland, Hans J. Neumann International Congress on Noise Control Engineering . 2012

机译：噪声对豚鼠张力Tympani肌肉自发收缩的影响
5. Molecular and biochemical changes in the ileum of weanling pigs fed antibiotics as growth promotant and in germ-free conditions [D] . George, Sajan 2006

机译：饲喂抗生素作为生长促进剂的断奶仔猪回肠的分子和生化变化以及无菌条件
6. The competitive antagonistic effect of compounds from Mandevilla velutina on kinin-induced contractions of rat uterus and guinea-pig ileum in vitro. [O] . J. B. Calixto, M. G. Pizzolatti, R. A. Yunes 1988

机译：扁桃（Mandevilla velutina）化合物对激肽诱导的大鼠子宫和豚鼠回肠收缩的竞争拮抗作用。
7. The competitive antagonistic effect of compounds from Mandevilla velutina on kinin-induced contractions of rat uterus and guinea-pig ileum in vitro. [O] . Calixto, J. B., Pizzolatti, M. G., Yunes, R. A. 1988

机译：扁桃（Mandevilla velutina）化合物对激肽诱导的大鼠子宫和豚鼠回肠收缩的竞争拮抗作用。

Pinacidil suppression on 5-HT_3 receptor-mediated contraction of guinea pig ileum in vitro

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