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首页> 外文期刊>Acta Pharmacologica Sinica >Effects of propafenone on electrophysiologic changes caused by alteration of left ventricular afterload in anesthetized rabbits
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Effects of propafenone on electrophysiologic changes caused by alteration of left ventricular afterload in anesthetized rabbits

机译:普罗帕酮对麻醉兔左室后负荷改变引起的电生理变化的影响

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AIM: To study effects of propafenone (Pro) on ventricular electrophysiologic changes mused by alteration of left ventricular afterload of rabbit heart. METHODS: Before and after iv Pro 3 mg·kg~-1, changing afterload of left ventricle (LV), occurrence of ventricular arrhythmia, left ventricular diastolic thresholds (VDT), relative refractory period (RRP), effective refractory period (ERP), dispersion of refractory period, and ventricular fibrillation threshold (VFT) were recorded. RESULTS: Increasing afterload of LV increased temporal dispersion of RRP and ERP [from 11±4 and 6±3 ms to 18±8 and 13± 8 ms (+△P = 8.4±2.9 kPa) individually ( P < 0.05)] and decreased VFT [from 5.5±1.0 V to 3.9 ±0.9 V (P<0.01)]; Ventricular arrhythmia was seen in all rabbits.
机译:目的:研究普罗帕酮(Pro)对兔心脏左心室后负荷改变引起的心室电生理变化的影响。方法:静脉注射Pro 3 mg·kg〜-1前后,左心室后负荷(LV)改变,室性心律失常的发生,左室舒张阈值(VDT),相对不应期(RRP),有效不应期(ERP)记录不应期的分散,心室纤颤阈值(VFT)。结果:LV后负荷的增加使RRP和ERP的时间分散性[从11±4和6±3 ms分别增加到18±8和13±8 ms(+△P = 8.4±2.9 kPa)(P <0.05)]和VFT降低[从5.5±1.0 V降至3.9±0.9 V(P <0.01)];在所有兔子中均观察到室性心律不齐。

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