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Engineering Sensor Arrays Using Aggregation-Induced Emission Luminogens for Pathogen Identification

机译：工程传感器阵列使用聚集诱导的发光原进行病原鉴定

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摘要

Lacking rapid and reliable pathogen diagnostic platforms, inadequate or delayed antimicrobial therapy could be made, which greatly threatens human life and accelerates the emergence of antibiotic-resistant pathogens. In this contribution, a series of simple and reliable sensor arrays based on tetraphenylethylene (TPE) derivatives are successfully developed for detection and discrimination of pathogens. Each sensor array consists of three TPE-based aggregation-induced emission luminogens (AIEgens) that bear cationic ammonium group and different hydrophobic substitutions, providing tunable logP (n-octanol/water partition coefficient) values to enable the different multivalent interactions with pathogens. On the basis of the distinctive fluorescence response produced by the diverse interaction of AIEgens with pathogens, these sensor arrays can identify different kinds of pathogens, even normal and drug-resistant bacteria, with nearly 100% accuracy. Furthermore, blends of pathogens can also be identified accurately. The sensor arrays exhibit rapid response (about 0.5 h), high-throughput, and easy-to-operate without washing steps.
机译：缺乏快速，可靠的病原体诊断平台，可能会导致抗菌治疗不足或延迟，这极大地威胁着人类的生命，并加速了抗生素耐药性病原体的出现。在这一贡献中，成功开发了一系列基于四苯乙烯（TPE）衍生物的简单可靠的传感器阵列，用于检测和区分病原体。每个传感器阵列均由三个带有阳离子铵基团和不同疏水取代基的基于TPE的聚集诱导发射发光剂（AIEgens）组成，可提供可调的logP（正辛醇/水分配系数）值，以实现与病原体的不同多价相互作用。基于AIEgen与病原体的多种相互作用所产生的独特荧光响应，这些传感器阵列可以以几乎100％的准确度识别出不同种类的病原体，甚至包括正常细菌和耐药菌。此外，还可以准确地识别病原体的混合物。传感器阵列显示快速响应（约0.5小时），高通量且易于操作，无需清洗步骤。

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  • 来源
    《Advanced Functional Materials》 |2019年第4期|1805986.1-1805986.10|共10页
  • 作者

    Zhou Chengcheng; Xu Wenhan; Zhang Pengbo; Jiang Meijuan; Chen Yuncong; Kwok Ryan T. K.; Lee Michelle M. S.; Shan Guogang; Qi Ruilian; Zhou Xin; Lam Jacky W. Y.; Wang Shu; Tang Ben Zhong;

  • 作者单位

    HKUST Shenzhen Res Inst, South Area, 9 Yuexing 1st RD,Hitech Pk, Shenzhen 518057, Peoples R China|Hong Kong Univ Sci & Technol, Ctr Tissue Restorat & Reconstruct, Hong Kong Branch Chinese Natl Engn Res, Dept Chem,Dept Chem & Biol Engn,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China;

    Hong Kong Univ Sci & Technol, Ctr Tissue Restorat & Reconstruct, Hong Kong Branch Chinese Natl Engn Res, Dept Chem,Dept Chem & Biol Engn,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China;

    Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, BNLMS, Beijing 100190, Peoples R China;

    HKUST Shenzhen Res Inst, South Area, 9 Yuexing 1st RD,Hitech Pk, Shenzhen 518057, Peoples R China|Hong Kong Univ Sci & Technol, Ctr Tissue Restorat & Reconstruct, Hong Kong Branch Chinese Natl Engn Res, Dept Chem,Dept Chem & Biol Engn,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China;

    HKUST Shenzhen Res Inst, South Area, 9 Yuexing 1st RD,Hitech Pk, Shenzhen 518057, Peoples R China|Hong Kong Univ Sci & Technol, Ctr Tissue Restorat & Reconstruct, Hong Kong Branch Chinese Natl Engn Res, Dept Chem,Dept Chem & Biol Engn,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China;

    HKUST Shenzhen Res Inst, South Area, 9 Yuexing 1st RD,Hitech Pk, Shenzhen 518057, Peoples R China|Hong Kong Univ Sci & Technol, Ctr Tissue Restorat & Reconstruct, Hong Kong Branch Chinese Natl Engn Res, Dept Chem,Dept Chem & Biol Engn,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China;

    Hong Kong Univ Sci & Technol, Ctr Tissue Restorat & Reconstruct, Hong Kong Branch Chinese Natl Engn Res, Dept Chem,Dept Chem & Biol Engn,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China;

    HKUST Shenzhen Res Inst, South Area, 9 Yuexing 1st RD,Hitech Pk, Shenzhen 518057, Peoples R China|Hong Kong Univ Sci & Technol, Ctr Tissue Restorat & Reconstruct, Hong Kong Branch Chinese Natl Engn Res, Dept Chem,Dept Chem & Biol Engn,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China;

    Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, BNLMS, Beijing 100190, Peoples R China;

    Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, BNLMS, Beijing 100190, Peoples R China;

    HKUST Shenzhen Res Inst, South Area, 9 Yuexing 1st RD,Hitech Pk, Shenzhen 518057, Peoples R China|Hong Kong Univ Sci & Technol, Ctr Tissue Restorat & Reconstruct, Hong Kong Branch Chinese Natl Engn Res, Dept Chem,Dept Chem & Biol Engn,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China;

    Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, BNLMS, Beijing 100190, Peoples R China;

    HKUST Shenzhen Res Inst, South Area, 9 Yuexing 1st RD,Hitech Pk, Shenzhen 518057, Peoples R China|Hong Kong Univ Sci & Technol, Ctr Tissue Restorat & Reconstruct, Hong Kong Branch Chinese Natl Engn Res, Dept Chem,Dept Chem & Biol Engn,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China|South China Univ Technol, Ctr Aggregat Induced Emission Guangzhou Int Campu, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Guangdong, Peoples R China;

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  • 关键词

    AIEgens; mathematical analysis; multivalent interaction; pathogen detection; simple and accurate;

    机译：AIEgens;数学分析;多价相互作用;病原体检测;简单准确;

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