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首页> 外文期刊>Advanced Functional Materials >A Nanoprobe for Diagnosing and Mapping Lymphatic Metastasis of Tumor Using 3D Multispectral Optoacoustic Tomography Owing to Aggregation/Deaggregation Induced Spectral Change
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A Nanoprobe for Diagnosing and Mapping Lymphatic Metastasis of Tumor Using 3D Multispectral Optoacoustic Tomography Owing to Aggregation/Deaggregation Induced Spectral Change

机译：由于聚集/解聚引起的光谱变化，使用3D多光谱光声层析成像技术诊断和定位肿瘤淋巴转移的纳米探针。

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摘要

Lymphatic metastasis of tumor is one of leading causes of cancer-related death, and diagnosing lymphatic metastasis is of significance in terms of optimal disease management and possible better outcomes for patients. Herein a turn-on optoacoustic nanoprobe is reported for noninvasively diagnosing and locating lymphatic metastasis in vivo. A positively charged tricyanofuran-containing polyene chromophore (TCHM) with high extinction coefficient is designed, synthesized, and allowed to form the nanoprobe with a negatively charged hyaluronan. The TCHMs take an aggregated state within the nanoprobe and exhibit weak absorption at 882 nm, the overexpressed hyaluronidase in cancer cells specifically degrades hyaluronan into small fragments and disaggregates TCHMs, thereby greatly enhancing the absorption at 882 nm and generating prominent optoacoustic signals. For multispectral optoacoustic tomography (MSOT) imaging in vivo, mice models with subcutaneous tumor and orthotopic bladder tumor are imaged first to demonstrate the nanoprobe's capability for detecting HAase-overexpressing tumors. A mouse model of lymphatic metastasis of tumor is then established and the lymphatic metastasis is successfully imaged and tracked optoacoustically. The imaging results were verified using multiple biochemical assays. Moreover, 3D MSOT renderings are obtained for precisely locating and tracking the metastasis of tumor in lymphatic system in a spatiotemporal manner.
机译：肿瘤的淋巴转移是癌症相关死亡的主要原因之一，从最佳疾病管理和患者可能获得更好结局的角度出发，诊断淋巴转移具有重要意义。在本文中，报道了一种打开式光声纳米探针，用于体内非侵入性诊断和定位淋巴转移。设计，合成具有高消光系数的带正电荷的含三氰呋喃的多烯发色团（TCHM），并使其与带负电的透明质酸一起形成纳米探针。 TCHM在纳米探针中处于聚集状态，在882 nm处表现出弱吸收，癌细胞中过表达的透明质酸酶将透明质酸特异降解为小片段，并分解TCHM，从而大大增强了882 nm处的吸收并产生显着的光声信号。对于体内多光谱光声层析成像（MSOT）成像，首先对具有皮下肿瘤和原位膀胱肿瘤的小鼠模型成像，以证明纳米探针检测过表达HAase的肿瘤的能力。然后建立了小鼠淋巴转移的小鼠模型，并通过声光成像成功地跟踪了淋巴转移。使用多种生化分析验证了成像结果。此外，获得了3D MSOT渲染图，以时空方式精确定位和跟踪淋巴系统中的肿瘤转移。

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  • 来源
    《Advanced Functional Materials》 |2019年第8期|1807960.1-1807960.13|共13页
  • 作者

    Wu Yinglong; Chen Junjie; Sun Lihe; Zeng Fang; Wu Shuizhu;

  • 作者单位

    South China Univ Technol, Coll Mat Sci & Engn, State Key Lab Luminescent Mat & Devices, Wushan Rd 381, Guangzhou 510640, Guangdong, Peoples R China;

    South China Univ Technol, Coll Mat Sci & Engn, State Key Lab Luminescent Mat & Devices, Wushan Rd 381, Guangzhou 510640, Guangdong, Peoples R China;

    South China Univ Technol, Coll Mat Sci & Engn, State Key Lab Luminescent Mat & Devices, Wushan Rd 381, Guangzhou 510640, Guangdong, Peoples R China;

    South China Univ Technol, Coll Mat Sci & Engn, State Key Lab Luminescent Mat & Devices, Wushan Rd 381, Guangzhou 510640, Guangdong, Peoples R China;

    South China Univ Technol, Coll Mat Sci & Engn, State Key Lab Luminescent Mat & Devices, Wushan Rd 381, Guangzhou 510640, Guangdong, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    3D imaging; aggregation; lymphatic metastasis; multispectral optoacoustic tomography; nanoprobe;

    机译：3D成像;聚集;淋巴转移;多光谱光声层析成像;纳米探针;

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