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首页> 外文期刊>Advanced Functional Materials >A Modular Vaccine Platform Combining Self-Assembled Peptide Cages and Immunogenic Peptides
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A Modular Vaccine Platform Combining Self-Assembled Peptide Cages and Immunogenic Peptides

机译：自组装肽笼和免疫原性肽相结合的模块化疫苗平台。

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摘要

Subunit vaccines use delivery platforms to present minimal antigenic components for immunization. The benefits of such systems include multivalency, self-adjuvanting properties, and more specific immune responses. Previously, the design, synthesis, and characterization of self-assembling peptide cages (SAGEs) have been reported. In these, de novo peptides are combined to make hubs that assemble into nanoparticles when mixed in aqueous solution. Here it is shown that SAGEs are nontoxic particles with potential as accessible synthetic peptide scaffolds for the delivery of immunogenic components. To this end, SAGEs functionalized with the model antigenic peptides tetanus toxoid(632-651) and ovalbumin(323-339) drive antigen-specific responses both in vitro and in vivo, eliciting both CD4(+) T cell and B cell responses. Additionally, SAGEs functionalized with the antigenic peptide hemagglutinin(518-526) from the influenza virus are also able to drive a CD8(+) T cell response in vivo. This work demonstrates the potential of SAGEs to act as a modular scaffold for antigen delivery, capable of inducing and boosting specific and tailored immune responses.
机译：亚单位疫苗使用递送平台来提供最少的抗原成分进行免疫。这种系统的好处包括多价，自我辅助特性和更特异性的免疫反应。以前，已经报道了自组装肽笼（SAGE）的设计，合成和表征。在这些肽中，从头肽结合在一起形成毂，当在水溶液中混合时，毂会组装成纳米颗粒。在此表明，SAGEs是无毒颗粒，具有潜在的可用于合成免疫肽的合成肽支架的能力。为此，用模型破伤风类毒素破伤风类毒素（632-651）和卵清蛋白（323-339）功能化的SAGE在体内和体外驱动抗原特异性应答，从而引起CD4（+）T细胞和B细胞应答。此外，用来自流感病毒的抗原肽血凝素（518-526）功能化的SAGEs还能在体内驱动CD8（+）T细胞应答。这项工作证明了SAGEs可以作为抗原递送的模块化支架，具有诱导和增强特异性和定制免疫反应的潜力。

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  • 来源
    《Advanced Functional Materials》 |2019年第8期|1807357.1-1807357.12|共12页
  • 作者

    Morris Caroline; Glennie Sarah J.; Lam Hon S.; Baum Holly E.; Kandage Dhinushi; Williams Neil A.; Morgan David J.; Woolfson Derek N.; Davidson Andrew D.;

  • 作者单位

    Univ Bristol, BrisSynBio, Bristol BS8 1TQ, Avon, England|Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England;

    Univ Bristol, Sch Cellular & Mol Med, Bristol BS8 1TD, Avon, England;

    Univ Bristol, Sch Cellular & Mol Med, Bristol BS8 1TD, Avon, England;

    Univ Bristol, BrisSynBio, Bristol BS8 1TQ, Avon, England|Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England|Univ Bristol, Sch Cellular & Mol Med, Bristol BS8 1TD, Avon, England;

    Univ Bristol, Sch Cellular & Mol Med, Bristol BS8 1TD, Avon, England;

    Univ Bristol, Sch Cellular & Mol Med, Bristol BS8 1TD, Avon, England;

    Univ Bristol, Sch Cellular & Mol Med, Bristol BS8 1TD, Avon, England;

    Univ Bristol, BrisSynBio, Bristol BS8 1TQ, Avon, England|Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England|Univ Bristol, Sch Biochem, Bristol BS8 1TD, Avon, England;

    Univ Bristol, Sch Cellular & Mol Med, Bristol BS8 1TD, Avon, England;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    coiled coils; peptide design; self-assembly; subunit vaccines; synthetic biology;

    机译：盘绕;肽设计;自组装;亚单位疫苗;合成生物学;

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