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Dual-Action Flexible Antimicrobial Material: Switchable Self-Cleaning, Antifouling, and Smart Drug Release

机译:双重作用的灵活抗菌材料:可切换的自洁,防污和智能药物释放

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摘要

A switchable material with a smart antimicrobial dual-action functionality, which is based on a highly stretchable silicon polymer gradiently doped with polyyrrole, is proposed. The material exhibits superhydrophobic and self-cleaning properties, high aerophilicity as well as the possibility of smart, electrically triggerable release of an incorporated drug. During the immersion of the material in water, an air gap is formed on its surface which prevents a formation of biofouling, attachment of microorganisms, and burst release of the incorporated drug. An application of external electric field switches the surface properties from the superhydrophobic to highly hydrophilic state that enables a wetting of the material surface and electrically triggered release of a loaded drug. After the electric field switching off and sample drying, the material surface returns to its intrinsic superhydrophobic state with the original self-cleaning properties so that the material surface can be simply cleaned, removing the bacteria. High flexibility and stretchability are additional favorable properties of the proposed smart antimicrobial material, making it a suitable candidate for a range of medical and related applications.
机译:提出了一种具有智能抗菌双重作用功能的可切换材料,该材料基于高度可拉伸的聚吡咯掺杂硅聚合物。该材料具有超疏水和自清洁性能,高嗜气性以及掺入药物智能,电触发释放的可能性。在将材料浸入水中的过程中,在其表面上会形成一个气隙,以防止形成生物污垢,附着微生物以及突然释放所掺入的药物。施加外部电场会将表面性质从超疏水状态切换为高度亲水状态,从而使材料表面变湿并通过电触发释放药物。关闭电场并干燥样品后,材料表面将恢复其固有的超疏水状态,并具有原始的自清洁特性,因此可以轻松清洁材料表面,去除细菌。高柔韧性和可拉伸性是拟议的智能抗菌材料的其他有利特性,使其成为一系列医疗和相关应用的合适候选者。

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