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Multipurpose Intraperitoneal Adhesive Patches

机译：多功能腹膜内贴剂

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摘要

The intraperitoneal (IP) cavity is the largest fluid-filled space in the body and contains important organs. Although peritoneal fluid from the abdominal cavity lubricates and allows organ motion, this fluid also effectively prevents polymeric material implantation. Anastomotic leakage after surgery has been reported but few sealing methods have been developed. Herein, a fluid-resistant adhesive called IP patch is reported that seals intestinal neo-anastomosis sites, preventing anastomotic leakage after colorectal surgery. The bursting pressure, which is the most important index of the degree of healing after colorectal anastomosis surgery, is measured from an IP patch applied to rats (188.3 +/- 14.5 mmHg) and is highly similar to the pressure observed from normal tissue (210.2 +/- 22.9 mmHg). Additionally, IP patches can act as unprecedented local drug reservoirs due to the aforementioned tissue adhesive property. Drug-loaded IP patches successfully treated multiple-site occurrence of small peritoneal cancerous colonies. The anticancer drug-loaded IP patches are applied to potential risk regions for recurrent and metastasized cancer in the IP cavity after the resection of peritoneal solid tumors. Thus, the multifunctionality of IP patches can be usefully exploited as an adhesive biomaterial that works effectively in difficult-to-treat diseases observed in IP environments.
机译：腹膜内（IP）腔是体内最大的液体填充空间，并包含重要器官。尽管来自腹腔的腹膜液可润滑并允许器官运动，但该液也有效地阻止了高分子材料的植入。据报道手术后吻合口漏，但很少开发出密封方法。在此，据报道称为IP贴剂的耐流体粘合剂密封肠的新吻合部位，防止大肠手术后的吻合口漏。爆破压力是结直肠吻合手术后愈合程度的最重要指标，是从应用于大鼠的IP贴片（188.3 +/- 14.5 mmHg）测得的，与正常组织的压力非常相似（210.2） +/- 22.9 mmHg）。另外，由于上述组织粘附特性，IP贴剂可以充当前所未有的局部药物储存库。载有药物的IP补丁成功治疗了小腹膜癌菌落的多部位发生。腹膜实体瘤切除后，将负载抗癌药物的IP贴片应用于IP腔中复发和转移的癌症的潜在风险区域。因此，IP贴片的多功能性可以有效地用作粘性生物材料，这种材料可以有效地治疗IP环境中难以治疗的疾病。

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  • 来源
    《Advanced Functional Materials》 |2019年第29期|1900495.1-1900495.10|共10页
  • 作者

    Ryu Ji Hyun; Kim Hyejin; Kim Kyuri; Yoon GhilSuk; Wang Younseon; Choi Gyu-Seog; Lee Haeshin; Park Jun Seok;

  • 作者单位

    Wonkwang Univ, Dept Carbon Convergence Engn, Iksan 54538, Jeonbuk, South Korea;

    Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Surg,Colorectal Canc Ctr, Daegu 41404, South Korea;

    Korea Adv Inst Sci & Technol, CNiT, Dept Chem, Daejeon 34141, South Korea;

    Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Pathol, Daegu 41404, South Korea;

    Korea Adv Inst Sci & Technol, CNiT, Dept Chem, Daejeon 34141, South Korea;

    Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Surg,Colorectal Canc Ctr, Daegu 41404, South Korea;

    Korea Adv Inst Sci & Technol, CNiT, Dept Chem, Daejeon 34141, South Korea;

    Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Surg,Colorectal Canc Ctr, Daegu 41404, South Korea;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    adhesive; anastomosis; cancer; patch; peritoneum;

    机译：胶粘剂;解剖;癌症;贴剂;腹膜;

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