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Inertial Microfluidics with Integrated Vortex Generators Using Liquid Metal Droplets as Fugitive Ink

机译:带有集成涡流发生器的惯性微流控,使用液态金属液滴作为逃逸墨水

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摘要

This work demonstrates a simple method for fabricating nearly spherical dome structures on top of lithographically defined microfluidic channels using gallium-based liquid metal droplets as fugitive ink. The droplets remain stable during the pouring and curing of polydimethylsiloxane and can be easily removed by applying a basic solution. This facilitates the formation of domes with diameters of a few hundred micrometers patterned on the desired locations of the channel. The expansion of the channel at the interface of the dome leads to formation of a large vortex inside the dome. Experiments using high-speed imaging along with numerical simulations show the utility of the vortex-induced flow rotation for orbiting of human monocytes and polystyrene microbeads inside the dome. The lateral displacement of liquids caused by the vortex is further utilized for creating controllable multiband flow/color profiles within a T-mixer. The method enables the fabrication of customized, complex, and 3D microfluidic systems utilizing planar microfabricated structures.
机译:这项工作演示了一种简单的方法,该方法使用镓基液态金属液滴作为逃生墨水,在光刻定义的微流体通道顶部制造近球形的圆顶结构。在聚二甲基硅氧烷的浇注和固化过程中,液滴保持稳定,可以通过施加碱性溶液轻松除去。这有助于形成在通道的期望位置上图案化的直径为几百微米的圆顶。在圆顶的界面处的通道的膨胀导致圆顶内部形成大涡旋。使用高速成像和数值模拟的实验表明,涡流诱导的流旋转可用于人单核细胞和聚苯乙烯微珠在圆顶内运行。由涡流引起的液体的横向位移还被用于在T混合器内产生可控制的多频带流动/颜色分布。该方法使得能够利用平面微制造的结构来制造定制的,复杂的和3D的微流体系统。

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