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Self-Adaptive Antibacterial Porous Implants with Sustainable Responses for Infected Bone Defect Therapy

机译：具有感染性骨缺损治疗可持续响应的自适应抗菌多孔植入物

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摘要

The development of responsive antibacterial implants is highly significant for the treatment of implant-associated infection. In this study, one self-adaptive antibacterial porous implant with sustainable responses is flexibly designed and constructed for infected bone defect therapy. Porous hydroxyapatite (HA) implants derived from nature bones, one typical implant, are first functionalized via low-cytotoxic ethanediamine-functionalized poly(glycidyl methacrylate) brushes, and gentamicin sulfate (CS, a kind of aminoglycoside antibiotic in clinic) is subsequently conjugated by an acid-responsive bond to produce smart antibacterial HA implants (HA-GS). The release of GS can be triggered by the acidic environment induced by the metabolism of bacteria for self-adaptive antibacterial response. Due to the good drug loading capacity and chemical stability of HA- GS in neutral condition, the sustainable antibacterial ability is readily achieved for long-term applications. The highly effective in vivo anti-infection therapy with HA-GS is demonstrated in one infected bone defect rabbit model. The implant-associated infection is completely inhibited by HA-GS at the early stage and the defected bones exhibit superior recovery at the late stage. This design strategy of sustainable self-adaptive antibacterial implants will provide a promising concept for the prevention and therapy of implant-associated infections.
机译：反应性抗菌植入物的开发对于与植入物相关的感染的治疗非常重要。在这项研究中，为感染的骨缺损治疗灵活地设计和构造了一种具有可持续响应的自适应抗菌多孔植入物。首先通过低细胞毒性乙二胺官能化的聚甲基丙烯酸缩水甘油酯刷对源自自然骨骼的多孔羟基磷灰石（HA）植入物进行功能化，然后通过硫酸酯化硫酸庆大霉素（CS，一种临床上的氨基糖苷类抗生素）进行缀合。产生酸响应的键，以生产智能的抗菌HA植入物（HA-GS）。 GS的释放可以由细菌代谢诱导的用于自适应抗菌反应的酸性环境触发。由于HA-GS在中性条件下具有良好的载药量和化学稳定性，因此长期应用很容易获得可持续的抗菌能力。在一种感染的骨缺损兔模型中证明了用HA-GS进行的高效体内抗感染治疗。植入物相关的感染在早期被HA-GS完全抑制，缺损的骨骼在晚期表现出优异的恢复能力。这种可持续的自适应抗菌植入物的设计策略将为预防和治疗植入物相关的感染提供有希望的概念。

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  • 来源
    《Advanced Functional Materials》 |2019年第17期|1807915.1-1807915.12|共12页
  • 作者

    Jin Xin; Xiong Yan-Hua; Zhang Xin-Yang; Wang Renxian; Xing Yonggang; Duan Shun; Chen Dafu; Tian Wei; Xu Fu-Jian;

  • 作者单位

    Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing Adv Innovat Ctr Soft Matter Sci & Engn,Mi, State Key Lab Chem Resource Engn,Key Lab Carbon F, Beijing 100029, Peoples R China;

    Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing Adv Innovat Ctr Soft Matter Sci & Engn,Mi, State Key Lab Chem Resource Engn,Key Lab Carbon F, Beijing 100029, Peoples R China;

    Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing Adv Innovat Ctr Soft Matter Sci & Engn,Mi, State Key Lab Chem Resource Engn,Key Lab Carbon F, Beijing 100029, Peoples R China;

    Beijing Jishuitan Hosp, Beijing Res Inst Traumatol & Orthopaed, Beijing Lab Biomed Mat, Lab Bone Tissue Engn, Beijing 100035, Peoples R China;

    Beijing Jishuitan Hosp, Beijing Res Inst Traumatol & Orthopaed, Beijing Lab Biomed Mat, Lab Bone Tissue Engn, Beijing 100035, Peoples R China;

    Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing Adv Innovat Ctr Soft Matter Sci & Engn,Mi, State Key Lab Chem Resource Engn,Key Lab Carbon F, Beijing 100029, Peoples R China;

    Beijing Jishuitan Hosp, Beijing Res Inst Traumatol & Orthopaed, Beijing Lab Biomed Mat, Lab Bone Tissue Engn, Beijing 100035, Peoples R China;

    Beijing Jishuitan Hosp, Beijing Res Inst Traumatol & Orthopaed, Beijing Lab Biomed Mat, Lab Bone Tissue Engn, Beijing 100035, Peoples R China;

    Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing Adv Innovat Ctr Soft Matter Sci & Engn,Mi, State Key Lab Chem Resource Engn,Key Lab Carbon F, Beijing 100029, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    antibacterial; implant; infection; self-adaptive; sustainable;

    机译：抗菌;植入物;感染;自适应;可持续;

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