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首页> 外文期刊>Advanced Functional Materials >Two-Stage Size Decrease and Enhanced Photoacoustic Performance of Stimuli-Responsive Polymer-Gold Nanorod Assembly for Increased Tumor Penetration
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Two-Stage Size Decrease and Enhanced Photoacoustic Performance of Stimuli-Responsive Polymer-Gold Nanorod Assembly for Increased Tumor Penetration

机译：响应性聚合物金纳米棒组件的两阶段尺寸减小和增强的光声性能，以增加肿瘤的穿透力。

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摘要

A promising theranostic platform for solid tumors would deliver and release anticancer nanomedicine effectively in tumor cells. However, diverse biological barriers, especially related to the tumor microenvironment, impede these theranostic agents from reaching the tumor cell. Herein, a sequential pH and reduction-responsive polymer and gold nanorod (AuNR) core-shell assembly to overcome these barriers via a two-stage size decrease and disassembly of the nanoplatform responding to the specified tumor microenvironment are reported. The tumor uptake of the hybrid nanoparticle (NP) is 14.2% ID g(-1), which is two and four times higher than the noneresponsive hybrid NPs and small AuNR@PEG, respectively. After tumor uptake of the hybrid NPs, the disassembled ultrasmall AuNRs coated with a polymer of polymerized reduction-responsive doxorubicin (DOX) prodrug monomers penetrate into the solid tumor and lead to localized DOX release in the tumor cell. A linear increase in photoacustic (PA) effects from the PA activating polymer on an AuNR cluster surface indicates a critical role of electromagnetic fields in the AuNR assembly, which is consistent with the theoretical calculation results. Furthermore, the hybrid NP can serve as a promising deep-tissue PA and surface-enhanced Raman scattering imaging agent for real-time in vivo investigation of physiological behaviors and deep tumor penetrating nanotherapy effects.
机译：一种有前途的实体瘤治疗学平台将在肿瘤细胞中有效地递送和释放抗癌纳米药物。但是，多种生物屏障，尤其是与肿瘤微环境有关的生物屏障，阻碍了这些治疗药物到达肿瘤细胞。在本文中，报道了依次进行pH和还原反应的聚合物和金纳米棒（AuNR）核-壳组件，以通过两步减小尺寸和响应特定肿瘤微环境的纳米平台拆卸来克服这些障碍。杂合纳米颗粒（NP）的肿瘤摄取为14.2％ID g（-1），分别比无反应杂合NP和小的AuNR @ PEG高2倍和4倍。肿瘤被杂合NP吸收后，涂有聚合的还原反应性阿霉素（DOX）前药单体的聚合物包裹的拆卸的超小AuNRs进入实体瘤并导致肿瘤细胞中局部DOX释放。 AuNR簇表面上来自PA活化聚合物的光声（PA）效应线性增加表明，电磁场在AuNR组件中起着至关重要的作用，这与理论计算结果一致。此外，杂合NP可以用作有前途的深层组织PA和表面增强拉曼散射成像剂，用于实时体内研究生理行为和深层肿瘤穿透纳米治疗效果。

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  • 来源
    《Advanced Functional Materials》 |2019年第16期|1806429.1-1806429.13|共13页
  • 作者

    Liu Tianji; Tong Lingling; Lv Ningning; Ge Xiaoguang; Fu Qinrui; Gao Shi; Ma Qingfie; Song Jibin;

  • 作者单位

    Jilin Univ, Dept Nucl Med, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China;

    Jilin Univ, Dept Nucl Med, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China;

    Jilin Univ, Dept Nucl Med, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China;

    Jilin Univ, Dept Nucl Med, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China;

    Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China;

    Jilin Univ, Dept Nucl Med, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China;

    Jilin Univ, Dept Nucl Med, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China;

    Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Fujian, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    cancer therapy; photoacoustic imaging; self-assembly; SERS; tumor microenvironment;

    机译：癌症治疗;光声成像;自组装;SERS;肿瘤微环境;

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