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首页> 外文期刊>Advanced Functional Materials >Multifunctional Nano-Biointerfaces: Cytocompatible Antimicrobial Nanocarriers from Stabilizer-Free Cubosomes
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Multifunctional Nano-Biointerfaces: Cytocompatible Antimicrobial Nanocarriers from Stabilizer-Free Cubosomes

机译：多功能纳米生物接口：来自无稳定剂的脂质体的细胞相容性抗菌纳米载体

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摘要

The rational design of alternative antimicrobial materials with reduced toxicity toward mammalian cells is highly desired due to the growing occurrence of bacteria resistant to conventional antibiotics. A promising approach is the design of lipid-based antimicrobial nanocarriers. However, most of the commonly used polymer-stabilized nanocarriers are cytotoxic. Herein, the design of a novel, stabilizer-free nanocarrier for the human cathelicidin derived antimicrobial peptide LL-37 that is cytocompatible and promotes cell proliferation for improved wound healing is reported. The nanocarrier is formed through the spontaneous integration of LL-37 into novel, stabilizer-free glycerol mono-oleate (GMO)-based cubosomes. Transformations in the internal structure of the cubosomes from Pn3m to Im3m-type and eventually their transition into small vesicles and spherical micelles are demonstrated upon the encapsulation of LL-37 into their internal bicontinuous cubic structure using small angle X-ray scattering, cryogenic transmission electron microscopy, and light scattering techniques. Additional in vitro biological assays show the antimicrobial activity of the stabilizer-free nano-objects on a variety of bacteria strains, their cytocompatibility, and cell-proliferation enhancing effect. The results outline a promising strategy for the comprehensive design of antimicrobial, cytocompatible lipid nanocarriers for the protection and delivery of bioactive molecules with potential for application as advanced wound healing materials.
机译：由于对常规抗生素具有抗性的细菌的出现越来越多，因此迫切需要对哺乳动物细胞毒性降低的替代抗菌材料进行合理设计。一种有前途的方法是基于脂质的抗菌纳米载体的设计。然而，大多数常用的聚合物稳定的纳米载体是细胞毒性的。本文中，报道了针对人cathelicidin衍生的抗菌肽LL-37的新型，无稳定剂的纳米载体的设计，该载体具有细胞相容性并促进细胞增殖以改善伤口愈合。纳米载体是通过将LL-37自发整合到新型，无稳定剂的单油酸甘油酯（GMO）的立方脂质体中而形成的。通过使用小角度X射线散射，低温透射电子将LL-37封装到其内部双连续立方结构中，证明了立方体的内部结构从Pn3m型转变为Im3m型，并最终转变为小囊泡和球形胶束显微镜和光散射技术。附加的体外生物学分析显示了不含稳定剂的纳米物体对多种细菌菌株的抗菌活性，它们的细胞相容性和促进细胞增殖的作用。该结果概述了一种抗微生物，细胞相容性脂质纳米载体的综合设计的有前途的策略，该载体可用于保护和递送生物活性分子，并有可能用作先进的伤口愈合材料。

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  • 来源
    《Advanced Functional Materials》 |2019年第35期|1904007.1-1904007.9|共9页
  • 作者

    Zabara Mahsa; Senturk Berna; Gontsarik Mark; Ren Qun; Rottmar Markus; Maniura-Weber Katharina; Mezzenga Raffaele; Bolisetty Sreenath; Salentinig Stefan;

  • 作者单位

    Empa, Swiss Fed Labs Mat Sci & Technol, Dept Mat Meet Life, Lab Biointerfaces, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland;

    Empa, Swiss Fed Labs Mat Sci & Technol, Dept Mat Meet Life, Lab Biointerfaces, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland;

    Empa, Swiss Fed Labs Mat Sci & Technol, Dept Mat Meet Life, Lab Biointerfaces, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland;

    Empa, Swiss Fed Labs Mat Sci & Technol, Dept Mat Meet Life, Lab Biointerfaces, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland;

    Empa, Swiss Fed Labs Mat Sci & Technol, Dept Mat Meet Life, Lab Biointerfaces, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland;

    Empa, Swiss Fed Labs Mat Sci & Technol, Dept Mat Meet Life, Lab Biointerfaces, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland;

    Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Lab Food & Soft Mat, Schmelzbergstr 9, CH-8092 Zurich, Switzerland;

    Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Lab Food & Soft Mat, Schmelzbergstr 9, CH-8092 Zurich, Switzerland;

    Empa, Swiss Fed Labs Mat Sci & Technol, Dept Mat Meet Life, Lab Biointerfaces, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland|Univ Fribourg, Dept Chem, Chemin Musee 9, CH-1700 Fribourg, Switzerland;

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  • 正文语种 eng
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  • 关键词

    antibacterial nanocarriers; antimicrobial peptides; cell proliferation; SAXS; stabilizer-free cubosomes;

    机译：抗菌纳米载体;抗微生物肽;细胞增殖;萨克斯;稳定剂 - 无核心;

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