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首页> 外文期刊>Advanced Functional Materials >Size-Transformable Metal-Organic Framework-Derived Nanocarbons for Localized Chemo-Photothermal Bacterial Ablation and Wound Disinfection
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Size-Transformable Metal-Organic Framework-Derived Nanocarbons for Localized Chemo-Photothermal Bacterial Ablation and Wound Disinfection

机译：尺寸可转换的金属有机骨架衍生的纳米碳，用于局部化学光热细菌消融和伤口消毒

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摘要

Severe infectious diseases caused by pathogenic bacteria have become urgent threats to global public health. Antibacterial materials with combined chemo-photothermal therapeutic capabilities possess distinct advantages when compared with many other antibacterial approaches. However, developing simplified and chemically tunable precursors to synthesize such antibacterial nanoagents for rapidly, safely, and synergistically combating pathogenic bacteria remains a huge challenge. Herein, metal-organic framework (MOF)-derived nanocarbons with near-infrared (NIR)-responsive and size-transformable capabilities are designed to overcome this challenge. The MOF-derived nanocarbons with chemo-photothermal bactericidal capabilities are first synthesized, and then coated with a thermoresponsive gel layer to obtain ON-OFF switching capability for bacterial trapping. The fabricated nanocarbons exhibit high photo-to-thermal conversion efficiency and fast size transformation from nanodispersions to micrometer aggregations upon NIR irradiation, thus enabling nanocarbons to generate localized massive heat and abundant Zn2+ ions for directly disrupting bacterial membrane and intracellular proteins. Furthermore, these nanocarbons not only exhibit a nearly 100% bactericidal ratio at very low dosage, but also possess highly efficient and safe wound disinfection activities, which are comparable to vancomycin. Overall, these proposed novel nanocarbons display robust and localized chemo-photothermal bactericidal capability and possess great potential to be used as alternative to antibiotics for broad-spectrum eradication of pathogenic bacteria.
机译：由病原菌引起的严重传染病已成为全球公共卫生的紧急威胁。与许多其他抗菌方法相比，具有化学光热治疗功能的抗菌材料具有明显的优势。然而，开发简化且化学可调的前体以合成此类抗菌纳米剂以快速，安全且协同地对抗病原菌仍然是巨大的挑战。在本文中，具有近红外（NIR）响应和尺寸可转换功能的金属有机骨架（MOF）衍生的纳米碳旨在克服这一挑战。具有化学光热杀菌能力的MOF衍生的纳米碳首先被合成，然后涂有热响应性凝胶层以获得用于细菌捕获的ON-OFF转换能力。制备的纳米碳在NIR照射下显示出高的光热转换效率以及从纳米分散体到微米聚集体的快速尺寸转换，因此使纳米碳能够产生局部大量热量和大量Zn2 +离子，从而直接破坏细菌膜和细胞内蛋白质。此外，这些纳米碳不仅在非常低的剂量下显示出近100％的杀菌率，而且具有与万古霉素相当的高效和安全的伤口消毒活性。总体而言，这些提出的新型纳米碳显示出强大的和局部的化学光热杀菌能力，并具有很大的潜力，可以用作广谱根除病原细菌的抗生素的替代品。

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  • 来源
    《Advanced Functional Materials》 |2019年第33期|1900143.1-1900143.14|共14页
  • 作者

    Yang Ye; Deng Yiyi; Huang Jianbo; Fan Xin; Cheng Chong; Nie Chuanxiong; Ma Lang; Zhao Weifeng; Zhao Changsheng;

  • 作者单位

    Sichuan Nivers, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Sichuan U Niversity 610065, Sichuan, Peoples R China;

    Sichuan Nivers, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Sichuan U Niversity 610065, Sichuan, Peoples R China;

    Sichuan Univ, Lab Ultrasound Imaging Drug, Dept Ultrasound, West China Sch Med,West China Hosp, Chengdu 610041, Sichuan, Peoples R China;

    Sichuan Nivers, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Sichuan U Niversity 610065, Sichuan, Peoples R China|Free Univ Berlin, Dept Chem & Biochem, Takustr 3, D-14195 Berlin, Germany;

    Sichuan Nivers, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Sichuan U Niversity 610065, Sichuan, Peoples R China|Free Univ Berlin, Dept Chem & Biochem, Takustr 3, D-14195 Berlin, Germany;

    Free Univ Berlin, Dept Chem & Biochem, Takustr 3, D-14195 Berlin, Germany;

    Sichuan Univ, Lab Ultrasound Imaging Drug, Dept Ultrasound, West China Sch Med,West China Hosp, Chengdu 610041, Sichuan, Peoples R China;

    Sichuan Nivers, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Sichuan U Niversity 610065, Sichuan, Peoples R China;

    Sichuan Nivers, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Sichuan U Niversity 610065, Sichuan, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    broad-spectrum bacterial killing; chemo-photothermal disinfection; metal-organic framework; near-infrared-responsive nanocarbons; size-transformable nanomaterials;

    机译：广谱细菌杀伤;化学光热消毒;金属有机框架;近红外响应纳米碳;尺寸可变形纳米材料;

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